Description
This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.
Table of Contents
Molecular Biotechnology: From DNA sequence to therapeutic protein.- Biophysical and Biochemical Analysis of Recombinant Proteins.- Production and purification of Recombinant Proteins.- Formulation of Biotech Products, including Biopharmaceutical Considerations.- Pharmacokinetics and Pharmacodynamics of Peptide and Protein Therapeutics.- Immunogenicity of Therapeutic Proteins.- Monoclonal Antibodies: From Structure to Therapeutic Application.- Genomics, Other “Omics” Technologies, Personalized Medicine and Additional Biotechnology-Related Techniques.- Dispensing Biotechnology Products: Handling, Professional Education and Product Information.- Economic Considerations in Medical Biotechnology.- Regulatory Framework for Biosimilars.- Insulin.- Follicle-Stimulating Hormone.- Human Growth Hormone.- Recombinant Coagulation Factors And Thrombolytic Agents.- Recombinant Human Deoxyribonuclease I.- Monoclonal Antibodies in Cancer.- Hematopoietic Growth Factors: Focuson Erythropoiesis-Stimulating Agents.- Monoclonal Antibodies in Solid Organ Transplantation.- Interferons and Interleukins.- Vaccines.- Oligonucleotides.- Gene Therapy.- Stem Cell Technology.
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