Description
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world.- Presents the only scientific reference to cover all of the nutritionally relevant essential major and trace minerals- Provides a broad introductory chapter on each mineral to give readers valuable background and context- Clarifies the cellular and molecular aspects of each mineral and its genetic and genomic aspects- Includes coverage of all nutritionally relevant minerals—essential major trace minerals and ultra-trace minerals- Underscores the important interactions between minerals so readers learn how metabolism of one mineral influences another
Table of Contents
Part I. Calcium1. Calcium-Sensing Receptor Polymorphisms and Human Disease2. Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis3. New Developments in Our Understanding of the Regulation of Calcium Homeostasis by Vitamin D4. Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator5. Calcium: Basic Nutritional Aspects6. Molecular Aspects of Calcium and Bone MineralizationPart II. Copper7. Copper: Basic Physiological and Nutritional Aspects8. Copper and Molecular Aspects of Cell Signaling9. Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression10. Copper in Wilson's and Alzheimer's Diseases, Copper-Lowering Therapy in Cancer and Other Diseases, and Copper DeficiencyPart III. Iodine11. Iodine: Basic Nutritional Aspects12. Iodine and Thyroid Hormone Synthesis, Metabolism, and Action13. Iodine and Adipocytokines: Cellular AspectsPart IV. Iron14. Iron: Basic Nutritional Aspects15. Hepcidin and the Hormonal Control of Iron Homeostasis16. Genetic Rodent Models of Systemic Iron Homeostasis17. Iron, Cancer, and Hypoxia-Inducible Factor Signaling18. Iron Transporters and Iron Homeostasis19. Regulation of Divalent Metal-Ion Transporter-1 Expression and FunctionPart V. Zin20. Discovery of Zinc for Human Health and Biomarkers of Zinc Deficiency21. Zinc Signals and Immune Function22. Posttranslational Mechanisms of Zinc Signaling23. Zinc Transporters in Health and Disease24. Genetic Study of Zinc Transporters and Zinc SignalingPart VI. Magnesium25. Magnesium: Basic Nutritional Aspects26. Magnesium and the Immune Response27. Magnesium Intake and Chronic Disease in Humans28. Magnesium and Embryonic Development29. Magnesium, Vascular Function, and HypertensionPart VII. Manganese30. Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication31. Manganese and Nutritional Immunity32. Manganese and Mitochondrial FunctionPart VIII. Molybdenum33. Molybdenum Cofactor in Humans: Health, Disease, and TreatmentPart IX. Phosphorus34. Phosphorus: Basic Nutritional Aspect35. Molecular Mechanisms of Adverse Health Effects Associated With Excess Phosphorus Intake36. Transcriptional Regulation of Sodium-Phosphate Cotransporter Gene ExpressionPart X. Selenium37. Selenium: Basic Nutritional Aspects38. Selenium and Cancer39. Could Selenium Be a Double-Edged Sword?Part XI. Electrolytes40. Sodium: Basic Nutritional Aspects41. Potassium Channel Mutations and Human Disease: Focus on Adrenal HypertensionPart XII. Nonessentials42. Chromium: Basic Nutritional and Toxicological Aspects43. Nonessential Trace Minerals: Basic Nutritional and Toxicological Aspects44. Fluoride: Intake and Metabolism, Therapeutic and Toxicological Consequences
