Description
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects.- Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects- Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness- Discusses clozapine rechallenge after each of its serious adverse reactions- Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy- Includes data on post-mortem considerations
Table of Contents
Part I: Cardiovascular Adverse Effects of Antipsychotic DrugsChapter 1 - Sudden Cardiac Death and Ventricular ArrhythmiasPeter Manu, Anca Dan and Gheorghe-Andrei DanChapter 2 - Myocarditis and CardiomyopathyKathlyn J. RonaldsonChapter 3 - Pulmonary EmbolismPeter Manu, Christopher Hohman, James F. Barrecchia, and Matisyahu ShulmanChapter 4 - Orthostatic HypotensionJames J. Gugger and Megan J. EhretPart II: Hematological Complications of Treatment With Antipsychotic DrugsChapter 5 - Severe Neutropenia and AgranulocytosisJohn Lally and Robert J. FlanaganPart III: Antipsychotic-Related Pathology of the Digestive SystemChapter 6 - Gastrointestinal Hypomotility and DysphagiaRobert J. Flanagan and Kathlyn J. RonaldsonChapter 7 - Liver FailureKatie F.M. Marwick8. PancreatitisPeter Manu, Matisyahu Shulman and Kathlyn J. RonaldsonPart IV: Major Neurological and Neuromuscular Adverse Effects of Antipsychotic DrugsChapter 9 - SeizuresTilman Steinert and Walter FröscherChapter 10 - Neuroleptic Malignant SyndromeJulie Langan Martin and Daniel J. MartinChapter 11 - Heat Stroke and RhabdomyolysisKathlyn J. RonaldsonPart V: Metabolic Complications of Antipsychotic Drug TreatmentChapter 12 - Type 2 Diabetes MellitusDavy Vancampfort, Richard I.G. Holt, Brendon Stubbs, Marc De Hert, Katherine Samaras and Alex J. MitchellPart VI: Other Life-Threatening Effects of Antipsychotic DrugsChapter 13 - Interstitial Nephritis and Interstitial Lung DiseaseKathlyn J. RonaldsonPart VII: Clinical and Forensic Challenges in the Use of Antipsychotic DrugsChapter 14 - The Benefits of Antipsychotic Drugs: Symptom Control and Improved Quality of LifeJian-Ping ZhangChapter 15 - Antipsychotic-Related Mortality: Risk and Strategy for Improved Clinical ManagementDan CohenChapter 16 - Forensic Investigation of Antipsychotic-Related DeathsRobert J. Flanagan and Peter Manu
