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Description
Completely revised and substantially extended to reflect the developments in this fast-changing field. It retains the interdisciplinary approach
that elegantly combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes.
It also covers recent advances in preparative chromatographic processes for the separation of "smaller" molecules using standard
laboratory equipment as well as the detailed conception of industrial chemical plants. The increase in biopharmaceutical substances is
reflected by new and revised chapters on different modifications of continuous chromatography as well as ion-exchange chromatography and
other separation principles widely used in biochromatography.
Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on stationary phases, selection of chromatographic
systems and process concepts. A completely new chapter deals with engineering and operation of chromatographic equipment. Final chapters on modeling and determination of model parameters as well as model based design, optimization and control of preparative chromatographic processes allow for optimal selection of chromatographic processes.
Essential for chemists and chemical engineers in the chemical, pharmaceutical, and food industries.
Table of Contents
Preface
INTRODUCTION
On the Development of Chromatography
Focus of the Book
Recommendation to read this Book
FUNDAMENTALS AND GENERAL TERMINOLOGY
Principles of Adsorption Chromatography
Basic Effects and Chromatographic Definitions
Fluid Dynamics
Mass Transfer Phenomena
Equilibrium Thermodynamics
Thermodynamic Effects on Mass Separation
STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS
Column Packings
Selection of Chromatographic Systems
CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION
Introduction
Engineering and Operational Challenges
Chromatography Columns Market
Chromatography Systems Market
Process Control
Packing Methods
Process Troubleshooting
Disposable Technology for Bio-Separations
PROCESS CONCEPTS
Discontinuous Processes
Continuous Processes
Choice of Process Concepts
MODELING AND MODEL PARAMETERS
Introduction
Models for Single Chromatographic Columns
Modeling HPLC plants
Calculations Methods
Parameter Determination
Experimental Validation of Column Models
MODEL BASED DESIGN, OPTIMIZATION AND CONTROL
Basic Principles and Definitions
Batch Chromatography
Recycling Chromatography
Conventional Isocratic SMB Chromatography
Isocratic SMB Chromatography under Variable Operating Parameters
Gradient SMB Chromatography
Multicolumn Systems for Bioseparations
Chromatographic SMB Reactors
Advanced Process Control
APPENDIX B
Data of Test Systems
