Neuropathology of Drug Addictions and Substance Misuse Volume 3 : General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions

著者名：Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, Victor R.

Academic Press（2016/04/25発売）

• 言語：ENG
• ISBN：9780128006344
• eISBN：9780128006771

Description

Neuropathology of Drug Addictions and Substance Misuse, Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions is the third of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader's knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 3 addresses prescription medications, caffeine, polydrug misuse, and non-drug addictions. Each section provides data on the general, molecular, cellular, structural, and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions.Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad of material and substances.- Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions- Fills an existing gap in the literature by serving as a "one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse- Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, full references- Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body

Table of Contents

Part I. Principles of Addictions, Overviews, Detailed Processes and MechanismsSection A. General AspectsChapter 1. Drugs and the Human EnviromeChapter 2. Psychoactive Plants Used during Religious RitualsChapter 3. Substance Use Disorders and Comorbid Mental Illness: A Focus on Epidemiological Data Regarding Mood and Anxiety DisordersChapter 4. Mephedrone and Mephedrone-Based Cocktails: Market, Analysis, Mechanisms of Action, and ToxicityChapter 5. Substance-Induced Psychosis: Conceptual and Diagnostic Challenges in Clinical PracticeChapter 6. Sleep and Drug AddictionSection B. Molecular and Cellular AspectsChapter 7. Hypothalamic and Midbrain Cells, Tyrosine Hydroxylase, and Implications for Drug AddictionChapter 8. Oxytocin: Providing New Avenues for Treating and Understanding Problematic Drug UseChapter 9. Role of D2-like Heteroreceptor Complexes in the Effects of Cocaine, Morphine, and HallucinogensChapter 10. Glutamate Receptors and Drug AddictionChapter 11. Effect of Interacting Nonsteroidal Anti-Inflammatory Agents (NSAIDs) and Opioids on Mood: Pharmacodynamic Considerations in Misuse and AbuseChapter 12. A Mini-Review on Different Commonly Used Abusive Drugs and the Interactions of These Drugs and Chinese HerbsChapter 13. Interaction of Drugs of Addiction with DNAChapter 14. Drugs of Abuse and DNA Methylation in the Brain: Ethanol, Cocaine, Amphetamine–Methamphetamine, Heroin, Antidepressants, and AntipsychoticsChapter 15. Orexin/Hypocretin System and Drug AddictionChapter 16. Reverse Translational Implications of Genome-Wide Association Studies for Addiction GeneticsChapter 17. Polymorphisms in the Delta Opioid Receptor Gene (OPRD1) and Drug Addiction: Candidate Genes, Transgenic Mouse Models, and Genome-Wide Association StudiesChapter 18. Drug Addictions and Genetics of the Dopamine PathwayChapter 19. In Silico Chemogenomics Knowledgebase and Computational System Neuropharmacology Approach for Cannabinoid Drug ResearchChapter 20. Cocaine- and Amphetamine-Regulated Transcript (CART) Peptide and Drug AddictionSection C. Structural and Functional AspectsChapter 21. The Cerebellar Landscape of Drug AddictionChapter 22. Movement Dysfunction as a Neuropathology of Illicit Stimulant AbuseChapter 23. Left Hemispheric "Imbalance in Drug AddictionChapter 24. Co-occurence of Substance Use and Personality Disorders: Epidemiology, Etiopathogenesis, and TreatmentChapter 25. Neonatal Abstinence Syndrome: Pharmacological AspectsChapter 26. Comorbidity between Substance Use Disorder and Severe Mental Illness: Dual DiagnosisPart II. Prescription Medications: DepressantsSection A. General AspectsChapter 27. Lormetazepam AddictionChapter 28. Prescribing and Dispensing of Benzodiazepines: Implications for Dependence and MisuseSection B. Molecular and Cellular AspectsChapter 29. Bidirectional Plasticity of Hippocampal Glutamate Receptors Is Central to Expression of Benzodiazepine Withdrawal-AnxietyChapter 30. Effect of Chronic Benzodiazepine Exposure on GABAA Receptors: Regulation of GABA/Benzodiazepine Site InteractionsChapter 31. The K+-Cl− Cotransporter KCC2 and ZolpidemSection C. Structural and Functional AspectsChapter 32. Benzodiazepine Misuse and Addiction. Risk Factors and Adverse Behavioral AspectsChapter 33. Benzodiazepines, Age-Related Pharmacological Changes, and Risk of Falls in Older AdultsChapter 34. The Substantia Nigra Pars Reticulata in Sedative-Hypnotic WithdrawalSection D. MethodsChapter 35. Assays for BenzodiazepinesPart III. Opioids and Morphine DerivativesSection A. General AspectsChapter 36. Weak Opioid Analgesics Abuse and Addiction: A Comparison of the Pharmacology and Pharmacoepidemiology of Codeine, Dihydrocodeine, and TramadolChapter 37. Maternal Codeine and Its Effect on the Fetus and Neonate: A Focus on Pharmacogenomics, Neuropathology, and WithdrawalChapter 38. Methadone Usage, Misuse, and Addiction Processes: An OverviewChapter 39.