Description
Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.
- Recognizes the critical importance of the Wnt signaling pathway for bone health
- Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
- Examines essential updates on estrogen prevention and treatment and the recent results from the WHO
- Discusses the controversial topics of screening and clinical trial design for drug registration
- Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
- Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics
Table of Contents
IntroductionThe Bone Organ System: Form and FunctionThe Nature of OsteoporosisThe Economics of OsteoporosisReflections on OsteoporosisSkeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of OsteoporosisBasic Science/Bone BiologyOsteoblast BiologyOsteoclast BiologyOsteocytesThe Regulatory Role of Matrix Proteins in Mineralization of BoneDevelopment of the SkeletonMouse Genetics as a Tool to Study Bone Development and PhysiologyParathyroid Hormone and Parathyroid Hormone-Related ProteinVitamin D: Biology, Action, and Clinical ImplicationsRegulation of Bone Cell Function by EstrogensAndrogens and Skeletal Biology: Basic MechanismsPhosphatoninsWnt Signaling in BoneCytokines and Bone RemodelingSkeletal Growth FactorsIntercellular Communication During Bone RemodelingStructural and BiomechanicsSkeletal Development: Mechanical Consequences of Growth, Aging and DiseaseInhibition of Osteoporosis by Biophysical InterventionBiomechanics of Age-Related FracturesBone QualityEpidemiology & Risk FactorsEpidemiologic Methods in Studies of OsteoporosisRace, Ethnicity and OsteoporosisThe Study of Osteoporotic Fractures (SOF): Major Findings and ContributionsBone Mineral Acquisition in Utero and During Infancy and ChildhoodBone Acquisition in Adolescence Genetic Determinants of Osteoporosis Nutrition and Risk for Osteoporosis Physical Activity in Prev
