ビタミンＤ（第２版・全２巻） Vitamin D（2）

著者名：Feldman, David (EDT)/Pike, J. Wesley (EDT)/Glorieux, Francis H. (EDT)

Academic Press（2005/01/25発売）

• 言語：ENG
• ISBN：9780122526879
• eISBN：9780080543642
• NDC分類：491.45

Description

Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.*Most comprehensive, up-to-date two-volume set on Vitamin D*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more*Further sections on emerging uses for treatments of auto-immune diseases and diabetes*Over 600 illustrations and figures available on CD

Table of Contents

INTRODUCTIONCH 1: Historical PerspectiveSECTION I: CHEMISTRY, METABOLISM, AND CIRCULATIONCH 2: Vitamin D Metabolism CH 3: Photobiology of Vitamin DCH 4: The Vitamin D-25 HydroxylaseCH 5: The 25-Hydroxyvitamin D 1-alpha-Hydroxylase CH 6: The 25-Hydroxyvitamin D 24-HydroxylaseCH 7: Mutant Mouse Models of Vitamin D Metabolic EnzymesCH 8: Vitamin D Binding Protein CH 9: New Aspects of DBPCH 10: Endocytic Pathways for 25-(OH) Vitamin D3SECTION II: MECHANISM OF ACTIONCH 11: The Vitamin D Receptor CH 12: Vitamin D Receptor Promoter and Regulation of Receptor Expression CH 13: Nuclear Vitamin D Receptor: Structure-Function, Molecular Control of Gene Transcription, and Novel Bioactions CH 14: Vitamin D Receptor Cofactors: Function, Regulation, and Selectivity CH 15: VDR LBD Crystal Structures CH 16: Comodulators of VDR-Mediated: Gene Expression CH 17: Promoter Targeting of VDR Through A Chromatin Remodeling Complex CH 18: Molecular Basis of the Diversity of Vitamin D Target Genes CH 19: Intranuclear Organization of the Regulatory Machinery for Vitamin D-Mediated Control of Skeletal Gene CH 20: Mouse Models of Vitamin D Receptor Ablation CH 21: Intranuclear Vitamin D Response Element Binding CH 22: VDR and RXR Subcellular Trafficking CH 23: 1a,25(OH)2¡Vvitamin D3 mediated rapid and genomic responses are dependent upon critical structure-function relationships for both the ligand and receptor(s) SECTION III: MINERAL HOMEOSTASISCH 24: Vitamin D and the Intestinal Absorption of Calcium: A View and Overview CH 25: Intestinal Calcium Absorption: Lessons from Knock Out Mice and Men CH 26: Phosphate Homeostasis CH 27: Mineralization CH 28: Modeling and Remodeling: How Bone Cells Work Together CH 29: Vitamin D and the Kidney CH 30: Vitamin D and the Parathyroids CH 31: Calcium-Sensing Receptor SECTION IV: TARGET ORGANS AND ACTIONS: A.