Description
A classic nephrology reference for over 25years, Seldin and Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch's The Kidney is your number one source for information.- Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters- Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation- Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions
Table of Contents
Section 1: Epithelial and Nonepithelial Transport and Regulation1 Epithelial Cell Structure and PolarityMichael Caplan2 Mechanisms of Ion Transport Across Cell Membranes & EpitheliaLuis Reuss and Guillermo Altenberg3 Renal Ion-Translocating AT Phases: The P-Type FamilyEric Feraille4 Mechanisms of Water Transport Across Cell Membranes & EpitheliaLuis Reuss and Guillermo Altenberg5 Cell Volume ControlFlorian Lang6 Soute Transport, Energy Consumption, and Production in the KidneyHitoshi Endou and Takashi Sekine7 Electrophysiological Analysis of Transepithelial TransportLawrence G. Palmer and Henry Sackin8 Ion Channels and Electro-physiological Properties of TransportJames Stockand9 Exchange of Fluid and Solutes Across Microvascular WallsC. Charles Michel10 External Balance of Electrolytes and Acids and AlkaliMan S. Oh11 CiliumBradley Yoder12 Inter-cellular JunctionsAlan S. L. Yu, Jano Peti-Perterdi, Fiona Hanner13 Principles of Cell SignalingLloyd Cantley14 Scaffolding Proteins in Transport RegulationPaul A. Welling15 The Renin-Angiotensin SystemThomas M. Coffman16 Neural Control of Renal FunctionUlla C. Kopp and EJ Johns17 Eicosanoids and the KidneyMatthew Breyer, Raymond C. Harris, Richard M. Breyer18 Extracellular Nucleotides and Renal FunctionRobert J. Unwin and David Shirley19 Paracrine Regulation of Renal Function by DopaminePedro JoseSection 2: Structural and Functional Organization of the Kidney20 Structural Organization of the Mammalian KidneyWilhelm Kriz and Brigitte Kaissling21 Biophysical Basis of Glomerular FiltrationRoland C. Blantz and Scott Thomson22 Glomerular Structure and Cell BiologySusan Quaggin23 Function of the Juxtaglomerular ApparatusJurgen Schnermann and Hayo Castrop24 Renal Cortical & Medullary MicrocirculationsThomas L. Pallone25 Molecular and Cellular Mechanisms of Kidney DevelopmentSanjay K. Nigam and Kevin T. Bush26 Molecular and Cellular Mechanisms of Glomerular Capilary DevelopmentJeffrey H. Miner and Dale R. Abrahamson27 Postnatal Renal DevelopmentMichael Baum28 Renal Hyperplasia and HypertrophyStuart J. Shankland29 Stem CellsQais Al-Awqati and Juan OliverSection 3: Fluid and Electrolyte Regulation and Dysregulation30 Epithelial Na+ ChannelsThomas R. Kleyman31 Anion ChannelsWilliam B. Guggino32 NaCL Co-transportersGerardo Gamba33 Sodium and Chlorid TransportAlan M. Weinstein34 Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct Gerardo Gamba and Laurent Schild35 Mineralocorticoid Action in the Aldosterone-Sensitive Distal NephronJohannes Loffing and Oliver Staub36 Inherited Disorders of Renal Salt Homeostasis: Insights From Molecular Genetics StudiesRick Lifton37 Natriuretic HormonesDavid L. Vesely38 Physiology & Pathophysiology of Sodium Retention and WastageBiff F. Palmer, Donald W. Seldin and Robert J. Alpern39 Physiology of HypertensionJohn E. Hall40 Physiology & Pathophysiology of Diuretic ActionDavid H. Ellison41 Aquaporin Water Channels in Mammalian KidneySoren Nielsen42 Thirst and VasopressinGary L. Robertson43 The Urine Concentrating Mechanism and Urea TransportersJeff M. Sands and Harold Layton44 HyponatremiaRichard H. Sterns45 Hypernatremic StatesLaurence Chan and Chris Rivard46 Polyuria and Diabetes InsipidusDaniel G. Bichet47 The Molecular Biology of Renal Potassium ChannelsWenhui Wang and Chou Long Huang48 Extrarenal Potassium MetabolismRobert M. Rosa49 Regulation of Potassium ExcretionGerhard Giebisch and Lisa Satlin50 Potassium DeficiencyGiovambattista Capasso, Miriam Zacchia and Francesco Trepiccione51 Clinical Disorders of HyperkalemiaMitchell Halperin and Kamel52 Control of Intracellular pHWalter F. Boron and Mark Bevensee53 Sodium-Coupled Bicarbonate TransportersIra Kurtz54 The SLC4 Anion Exchanger Gene FamilySeth Alper55 Cellular Mechanisms of Renal Tubular AcidificationPatricia Preisig, L.
