Description
Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic.As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials.Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic.- Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials- Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis- Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI- Covers the prevailing opinions on how to harness the body's natural repair mechanisms- Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals
Table of Contents
1. Introduction and Overview of Stem Cells2. Mechanistic Insights from Pathologic Perspective3. Large Animal Models to Study Stem Cell Therapy4. Evolution of understanding of the mechanisms of repair5. Impact of Age on Stem Cell Function6. Bone Marrow Mononuclear Cells7. Chronic Limb Ischemia8. Chronic/Refractory Angina9. Acute Myocardial InfarctionA. European ExperienceB. US Experience10. Chronic Ischemic Heart Failure11. Adipose Tissue12. Overview of MSCs 13. Allogeneic vs Autologous Source: Comparative Effects14. Use of MSCs for AMI15. Combined Cell Strategies16. Heart Failure17. C-Kit+ cells18. Cardiospheres19. Umbilical Cord, Placenta, Endometrium20. Genetic Engineering of Fibroblasts to Cardiomyocytes21. Transformation to inducible Pleuripotent Stem Cells22. Transformation to MAPC's23. Transcoronary and Endocardial24. Retrograde and Epicardial25. Epicardial Patch26. Matrix Scaffolds27. Matrix plus cells 28. Biomaterial: Alginate29. Organogenesis30. Pre-clinical Identification of target genes31. SERCA-2a gene for recovery of inotropic function32. SDF-1 Gene for Heart Failure Non-Inotropic Mechanisms33. Gene Therapy for Angiogenesis: Chronic Limb Ischemia 34. Stem Cells Target Gene Transfected Stem Cells35. CCTRN: Past, Present, and Vision for the Future36. Signature of Responders-lessons from Bio-Repository37. Adjunctive therapy with LVADs for Recovery38. Trials in Non-Ischemic Heart Failure39. Enhancing Stem Cell Homing for Tissue Repair40. Stroke: Pre-Clinical and Clinical Trial Data
