Description
Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.- Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes- Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials- Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy
Table of Contents
1. Introduction to Epigenetics2. Laboratory Methods in Epigenetics3. Keratinocyte Differentiation and Epigenetics4. Fibroblast Differentiation and Epigenetics5. Epigenetic Modulation on Hair Follicle Stem Cells6. Epigenetics and the Regulation of Inflammation7. Malignant Transformation and Epigenetics8. Sirtuins and Epigenetics and Dermatology9. MicroRNAs in Skin Diseases10. Systemic Lupus Erythematosus11. Psoriasis12. Scleroderma13. Allergic and Inflammatory Skin Diseases14. Other Autoimmune Diseases15. Infectious Skin Diseases16. Melanoma17. Cutaneous T-cell Lymphoma18. Aging19. Diagnostic Techniques Employing Epigenetics20. Therapeutic Approaches using Epigenetics21. The Changing World and Epigenetics – How the Environment Influences Epigenetics
