Description
Segmented Negative Strand Viruses: Arenaviruses, Bunyaviruses, and Orthomyxoviruses is a collection of proceedings presented at the 5th International Symposium on Negative Strand Viruses, held at Hilton Head, South Carolina, on September 11-17, 1983. The papers focus on three virus families with segmented negative RNA genomes: arenaviruses, bunyaviruses, and orthomyxoviruses. Emphasis is placed on the viruses' replication strategies, gene organization, and biochemical and biological properties. Comprised of 56 chapters, this volume begins with an introduction to the genome structure, transcription, and genetics of arenaviruses, bunyaviruses, and orthomyxoviruses. The next section is devoted to these viruses' gene expression, protein synthesis, and protein modification. Eukaryotic expression of cloned complementary DNA coding for influenza is considered, along with the functional expression and mutational analysis of influenza virus surface glycoproteins. Subsequent chapters explore viral proteins via antigenic and functional analyses; the biology and immunochemistry of the African arenaviruses Lassa and Mopeia; and the use of avian-human reassortant influenza A viruses as live vaccine viruses in humans. This book will be of interest to investigators, microbiologists, and molecular and cell biologists in fields such as molecular biology, genetics, viral immunology, infectious diseases, and vaccine development.
Table of Contents
ContributorsPrefaceContents of Nonsegmented Negative Strand VirusesGenome Structure, Transcription, and Genetics Coding Analyses of Bunyavirus RNA Species Molecular Cloning of the Bunyamwera Virus Genome Hybrid Selection of Viral mRNA using cDNA Clones of Inkoo Virus M Gene Rift Valley Fever Virus Intracellular RNA: A Functional Analysis Transcription of the S RNA Segment of Germiston Bunyavirus The S Segment of Bunyaviruses Codes for Two Complementary RNAs Restriction of Subunit Reassortment in the Bunyaviridae Genetic Analyses of Pichinde and LCM Arenaviruses: Evidence for a Unique Organization for Pichinde S RNA Studies on the Molecular Biology of Lymphocytic Choriomeningitis Virus Sequence Rearrangements in Influenza Virus RNA and Ribonucleoprotein Structure Molecular Topography of the Influenza Virus P Protein Complex during Capped RNA-Primed Messenger RNA Synthesis In Vivo Transcription and Translation of Defective-Interfering Particle-Specific RNAs of Influenza Virus Mutants Obtained following Undiluted Passage of an Influenza A (Fowl Plague) Virus Genetic Stability of A/Ann Arbor/6/60 Cold-Mutant (Temperature-Sensitive) Live Influenza Vaccine StrainsGene Expression, Protein Synthesis, and Protein Modification Subgenomic RNA of Arenavirus Pichinde and its Implication in Regulation of Viral Gene Expression in Productive Infection and Persistence Biochemical Characterization of Hantaan Virus Eukaryotic Expression of Cloned cDNA Coding for Influenza Viral Glycoproteins using an SV40 Vector: Use of Recombinant DNA Mutants to Study Structure-Function Relationships Studies on the Second Protein Encoded by the Neuraminidase Gene of Influenza B Virus Functional Expression and Mutational Analysis of Influenza Virus Surface Glycoproteins The Nonstructural Gene Segment of Influenza A Virus: Expression of NS1 Protein in Mammalian Cells; Analysis of a Deletion Mutant Production of a Subunit Vaccine for Rift Valley Fever Virus Persistent Expression of Influenza Virus Nucleoprotein in Recombinant DNA-Transfected Mouse Cells Expression of Influenza Virus Subgenomic Virion RNAs in Infected Cells Transport of Viral Glycoprotein and its Modulation by Monensin Interfering with Glycoprotein Processing in Influenza and Sindbis Virus-Infected CellsViral Proteins: Antigenic and Functional Analyses Antigenic and Structural Studies on the Glycoproteins of Lymphocytic Choriomeningitis Virus Comparative Analysis of Lassa and Lassa-Like Arenavirus Isolates from Africa Neutralization of Arenaviruses: Reaction of Tacaribe Virus and Variants with Monoclonal Antibodies Antigenic Sites on the Gl Glycoprotein of La Crosse Virus that are Involved in Neutralization Influenza Virus Neuraminidase: Structure and Variation Pleiotropic Effects of a Single Amino Acid Change on Antigenicity and Biologic Function of Swine Influenza Virus Hemagglutinin Mutants Selection of Receptor Variants from Human and Avian Influenza Isolates with the H3 Hemagglutinin Antigenic Alterations of the Influenza Virus Hemagglutinin during the Infectious Cycle Antigenic Drift of the H1 Subtype Hemagglutinin from 1977 to 1980 The Binding Sites to Monoclonal Antibodies on A/USSR/90/77 (H1N1) Hemagglutinin Structure of the Cleavage Site of Hemagglutinins of Pathogenic and Nonpathogenic H7 Influenza Viruses An Influenza Virus Mutant Whose Lesion Results in Temperature-Sensitive Hemagglutination The Carbohydrates of the Hemagglutinin of Influenza Virus Heterogeneity of the Membrane (M1) Protein of Influenza Virus Antigenic Characterization of Influenza A Matrix Protein with Monoclonal Antibodies Evolutionary Conservation of Influenza Nucleoprotein Genes in Host Species Virus-Specific Polypeptides in Cells Infected with Influenza C, Dhori, and Thogoto VirusesBiology Mechanism of Persistent LCMV Infection in Mice: Role of
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