Description
Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.- Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas- Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications- Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs
Table of Contents
1. Introduction2. DNA Methylation & Hydroxymethylation in Cancer3. Writers, Readers, and Erasers of Epigenetic Marks4. MicroRNAs and Cancer5. Long Noncoding RNAs (lncRNAs) and Cancer6. Ribosomal RNA Methylation and Cancer7. Mining the Epigenetic Landscape: Surface Mining or Deep Underground8. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality9. Epigenetic Therapy in Lung Cancer and Mesothelioma10. Breast Cancer Epigenetics11. Therapeutic Applications of the Prostate Cancer Epigenome12. Liver Cancer (Hepatocellular Carcinoma)13. Neuroblastoma14. The Epigenetics of Medulloblastoma15. Clinical Significance of Epigenetic Alterations in Glioblastoma16. Esophageal Cancer17. Nasopharyngeal Cancer18. Nutritional Epigenetic Inhibitors in the Field of Cancer: New Avenues for Chemopreventive Approaches19. Emerging Epigenetic Therapies – Lysine Methyltransferase/PRC Complex Inhibitors20. Inhibitors of Jumonji C Domain Histone Demethylases21. Emerging Epigenetic Therapies – Lysine Acetyltransferase Inhibitors22. Emerging Epigenetic Therapies – Bromodomain Ligands23. Clinical Trials24. Genetic Intratumor Heterogeneity25. Epigenetics Underpinning DNA Damage repair26. Epigenetics of Cisplatin Resistance27. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells28. Personalized Therapy – Chemosensitivity Testing29. Personalized Therapy - Epigenetic Profiling as Predictors of Prognosis and Response
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