Immunopotentiators in Modern Vaccines

著者名：Schijns PhD, Virgil E.J.C. (EDT)/O'Hagan PhD, Derek T. (EDT)

Academic Press（2005/12/19発売）

• 言語：ENG
• ISBN：9780120884032
• eISBN：9780080457215
• NDC分類：492.39

Description

Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations.- Contributions from leading international authorities in the field- Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system- Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Table of Contents

PrefaceList of contributorsPart I: Perspective on immunological mechanisms underlying adjuvant activityChapter 1: Unraveling “the immunologist's dirty little secretâ€Part II: Host-derived immunopotentiatorsChapter 2: Dendritic cells as targets and tools in vaccinesChapter 3: Host-derived molecules as adjuvantsPart III: Natural and synthetic immunopotentiatorsChapter 4: Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvantsChapter 5: CpG oligodeoxynucleotides as vaccine adjuvantsChapter 6: Toll-like receptor 4 agonists as vaccine adjuvantsChapter 7: Immunomodulatory adjuvants from Quillaja saponariaPart IV: Particulate immunopotentiators and delivery systemsChapter 8: Microparticles as vaccine delivery systemsChapter 9: MF59: a safe and potent adjuvant for human useChapter 10: Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminum saltChapter 11: Virosomes for vaccine deliveryChapter 12: The ISCOMATRIXâ"¢ adjuvantChapter 13: Mineral adjuvantsPart V: Mucosal/nonparenteral adjuvantsChapter 14: Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxinChapter 15: Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvantPart VI: Th-1/CTL adjuvantsChapter 16: T cell adjuvants and novel strategies for their identificationPart VII: Adjuvants in noninfectious disease vaccinesChapter 17: Vaccination to treat noninfectious diseases: surveying the opportunitiesPart VIII: Clinical practiceChapter 18: Clinical evaluation of adjuvantsChapter 19: Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccinesIndex