Description
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This 3e includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must-have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.
Table of Contents
Section I: Chemistry, Metabolism, Circulation1 Historical Overview of Vitamin DHector F. Deluca2 Photobiology of Vitamin DMichael F. Holick3 The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)Glenville Jones and David E. Prosser4 CYP24A1: Structure, Function, and Physiological RoleRene St. Arnaud5 The Vitamin D Binding Protein: DBPRoger Bouillon6 Industrial Aspects of Vitamin DArnold L. HirschSection II: Mechanisms of Action7 VDRJ. Wesley Pike8 Nuclear Vitamin D Receptor: Natural Ligands, Molecular Structure-Function, and Transcriptional Control of Vital GenesMark R. Haussler, Carol A. Haussler, Jui-Cheng Hsieh, Peter W. Jurutka, and G. Kerr Whitfield9 Structural Basis for Ligand Activity in VDRDino Moras and Natacha Rochel10 Coregulators of VDR-mediated Gene ExpressionPaul McDonald and Diane R. Dowd11 Target Genes of Vitamin D: Spatio-temporal Interaction of Chromatin, VDR and Response ElementsCarsten Carlberg12 Epigenetic Modifications in Vitamin D Receptor Mediated TransrepressionShigeaki Kato, Alexander Kouzmenko, Fumiaki Ohtake, and Ryoji Fujiki13 Vitamin D and Wnt/ß-Catenin SignalingAlbert Munoz, José Manuel González-Sancho, and María Jesús Larriba14 Vitamin D Response Element Binding ProteinJohn S. Adams, Thomas S. Lisse, Hong Chen, Mark S. Nanes, and Martin Hewison15 Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic ActionsAnthony W. Norman and Mathew T. MizwickiSection III: Mineral and Bone Homeostasis16 Development of the SkeletonJane B. Lian, Gary S. Stein, Martin Montecino, Janet L. Stein, Andre J. van Wijnen17 Vitamin D Regulation of Osteoblast FunctionRenny Franchesci and Yan Li18 OsteoclastsF. Patrick Ross19 Molecular Mechanisms for Regulation of Intestinal Calcium and Phosphate Absorption by Vitamin DJames Fleet and Ryan D. Schoch20 The Calbindins: Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV6Sylvia Christakos, Leila Mady, and Puneet Dhawan21 MineralizationAdele Boskey and Eve Donnelly22 VITAMIN D REGULATION OF TYPE I COLLAGEN EXPRESSION IN BONEBarbara Kream and Alexander Lichtler23 Target Genes: Bone ProteinsHoward Morris, Paul H. Anderson, Gerald J. Atkins, and David M. Findlay24 Vitamin D and the Calcium-Sensing ReceptorEdward M. Brown25 Effects of 1,25-Dihydroxyvitamin D3 on Voltage-Sensitive Calcium Channels in Osteoblast Differentiation and MorphologyMary Farach-Carson and William R. ThompsonSection IV: Targets (David/John/Wes)26 Vitamin D and the KidneyRajiv Kumar and Peter Tebben27 Vitamin D and the ParathyroidsJustin Silver and Tally Neveh-Many28 CartilageBarbara D. Boyan, Maryam Doroudi and Zvi Schwartz29 Vitamin D and Oral HeathAriane Berdal, Muriel Molla, Vianney Descroix30 The Role of Vitamin D and its Receptor in Skin and Hair Follicle BiologyMarie B. Demay31 Vitamin D and the Cardiovascular SystemDavid Gardner, Songcang Chen, Denis Glenn, and Wei Ni32 Vitamin D: A Neurosteroid Affecting Brain Development and Function; Implications for Neurological and Psychiatric DisordersJohn McGrath, Darryl Eyles, and Thomas Burne33 Contributions of Genetically Modified Mouse Models to Understanding the Physiology and Pathophysiology of the 25-hydroxyvitamin D-1-alpha Hydroxylase Enzyme [1a(OH)ase] and the Vitamin D Receptor (VDR)David Goltzman, Geoffrey N. Hendy, and Richard KremerSection V: Human Physiology34 Vitamin D: Role in the Calcium and Phosphorus EconomiesRobert P. Heaney35 Fetus, Neonate and InfantChris Kovacs36 Vitamin D Deficiency and Calcium Absorption During ChildhoodSteven A. Abrams37 Adolescence and Acquisition of Peak Bone MassConnie Weaver, Rick Lewis, and Emma Liang38 Vitamin D Metabolism in Pregnancy and LactationBonny Specker, Natalie W. Thiex, and Heidi J. Kalkwarf39 Vitamin D: Relevance in Reproductive Biology and Pathophysiological Implications in Reproductive DysfunctionHugh S.
