Full Description
Cytokine and Chemokine Networks in Cancer" provides a comprehensive exploration of the roles of cytokines and chemokines in cancer biology. It offers valuable insights into their diagnostic, prognostic, and therapeutic implications, making it a valuable resource for researchers, clinicians, and students interested in the field of cancer immunology and therapy. This book illustrates the importance and significance of the cytokine and chemokine signaling networks in tumor development and progression. It describes the complex networks mediated by cytokine and chemokine receptors promoting tumor cell proliferation, site-directed metastasis, and activation of angiogenic switch in tumor cells. The books also shed light on the heterogeneity of cytokines and chemokine in solid malignancies and their impact on tumor progression and therapeutic outcomes. The chapters provide current information about the types of cytokine-chemokine interactions in promoting cancer stem cell-like characteristics, epithelial to mesenchymal transition, and modulation of the tumor microenvironment. The significance of the complex interactions in cancer biology in the light of therapeutic resistance is also highlighted. The chapters also describe recent advancements in the therapeutic potential of targeting the pro-tumor cytokine and chemokine networks and limiting tumor cell metastasis. Finally, the book also provides a comprehensive yet representative description of a large number of challenges associated with targeting these vital chemokine-cytokine networks. Given its content, the book provides valuable information for researchers in the field of cancer biology and molecular medicine.
Contents
Chapter 1_Introduction to Cancer.- Chapter 2_Expression pattern of Chemokines in Cancer.- Chapter 3_Implications of Cytokine-Chemokine Heterogenity in Cancer.- Chapter 4_Cytokine and chemokines networks in cancer stemness.- Chapter 5_Cytokine and chemokines networks in angiogeneis.- Chapter 6_Role of Cytokine-Chemokine cascades in Epithelial to Mesenchymal Transition.- Chapter 7_Role of Chemokines in establishment of Metastatic Niche.- Chapter 8_CXCL12-CXCR4 axis in Metastasis.- Chapter 9_Chemokine and cytokine networks in the tumor microenvironment.- Chapter 10_CXCL9, CXCL10, CXCL11/CXCR3 axis and Immune Activation.- Chapter 11_CXCL8-CXCR1/2 axis in cancer and inflammatory diseases.- Chapter 12_Cytokine and Chemokine Networks in Therapeutic Resistance.- Chapter 13_Prognostic and diagnostic significance of Chemokines and cytokines in cancer.- Chapter 14_Therapeutic implications of Chemokines and cytokines networks in cancer.- Chapter 15_Chemokines in cancer therapy.
