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Full Description
This book offers a basic understanding of the complex mechanisms that protect the brain from harmful substances while still allowing for essential functions such as nutrient transport and waste removal. It explores the blood-cerebrospinal fluid barrier (BCSFB) and the blood-brain barrier (BBB) in depth, focusing on the latest research, innovative techniques, and unique perspectives from researchers worldwide. The book also examines the clinical relevance of brain barrier dysfunction, with a particular focus on multiple sclerosis (MS) and the potential role of brain barriers in the development of MS, intricate relationship between brain barriers and infectious diseases and much more. With contributions from experts in neurobiology, microbiology, and biophysics, this book provides a multidisciplinary perspective.
Extensive research has been conducted on the cerebrovascular or cerebrospinal fluid barrier function. The recent development of a functional epithelial cell line derived from a human choroid plexus papilloma has paved the way for an in vitro model of the choroid plexus, which has been instrumental in elucidating the interplay between infection, metabolism, physiological functions, and disease. This book is an effort by the Editors to raise public knowledge of the cerebrovascular and cerebrospinal fluid barriers.
With broad coverage of topics in "Human Cerebrospinal Fluid and Cerebrovascular Barrier", it is ideal for researchers studying cerebrovascular or cerebrospinal fluid barrier interested in staying up to date on the latest developments. Healthcare providers and researchers working to develop new treatments for MS, infectious diseases of the central nervous system and other neurological disorders will also value this book. The book provides students of medicine, pharmacy, biology, and engineering with a comprehensive understanding of the structure and function of brain barriers. Those seeking a thorough introduction to the field will also find the book enjoyable.
Contents
Part 1 BBB & BCSFB introductions.- 1 The History of the Blood-CNS-barriers.- Part 2 BCSFB/HIBCPP.- 2 An overview of human choroid plexus structure and transport functions.- 3 Detailed protocol for establishing HIBCPP cell line derived from human choroid plexus papilloma: Special reference to the neuroprotective effects of transthyretin produced by HIBCPP cells.- 4 Bitter taste receptors as gatekeepers of brain barriers.- 5 Changes in the Blood Choroid Plexus Barrier in Response to Transient Receptor Potential, Vanilloid 4 Channel Activation.- 6 The blood-cerebrospinal fluid barrier and brain manganese accumulation.- 7 "Autoimmune interactions of antibacterial antibodies with brain proteins on choroid plexus cells: is there a role for neurodevelopmental disorders?".- 8 Multiple Sclerosis and the blood‒cerebrospinal fluid barrier.- 9 Viral infections of the CNS - is it all about breaching barriers?.- 10 The Choroid Plexus: A Barrier to the Brain and a Target for Central Nervous System-Invading Bacteria.- 11 Brain Infection in African Sleeping Sickness.- 12 The Blood-CSF Barrier in Oncological Research.- Part 3 BBB.- 13 In vitro models of the blood-brain barrier to study multiple sclerosis pathogenesis.- 14 Construction and Functional Evaluation of 2D and 3D Human Blood-Brain Barrier Models.
