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Full Description
This book covers two decades of the author's studies about fetal-originated diseases. It contains researches from the aspects of multiple inducing factors of fetal-originated diseases, including prenatal xenobiotic exposure, nutritional deficiency and other adverse environment during pregnancy. The authors introduce a series of animal models for studying the fetal origin of a variety of metabolic and neuropsychiatric diseases, and propose the mechanisms of developmental toxicity and susceptibility to multiple diseases, such as glucocorticoid programming. Moreover, the extended knowledge are also clearly addressed, like identification of biomarkers of developmental toxicity, and the strategies for early warning, prevention and treatment of fetal-originated diseases. Thus, the book is a systematic and complete reference for the researchers of related areas.
Contents
Chapter 1. Prenatal Adverse Environment and Susceptibility to Fetal-originated Disease.- Chapter 2. Molecular Mechanism of Fetal Developmental Toxicity.- Chapter 3. Epigenetic Mechanism of Fetal-originated Disease.- Chapter 4. Neuroendocrine Programming Mechanism of Fetal-originated Disease.- Chapter 5. Glucocorticoids Programming Mechanism of Fetal-originated Disease.- Chapter 6. Gut Microbiota Mechanism of Fetal-originated Disease.- Chapter 7. Sex Difference of Fetal-originated Disease.- Chapter 8. Multigenerational Genetic Effect of Fetal-originated Disease.- Chapter 9. Developmental Toxicity of Caffeine and Related Fetal-originated Disease.- Chapter 10. Developmental Toxicity of Dexamethasone and Related Fetal-originated Disease.- Chapter 11. Fetal Origin of Metabolic Syndrome.- Chapter 12. Fetal Origin of Diabetes.- Chapter 13. Fetal Origin of Non-alcoholic Fatty Liver Disease.- Chapter 14. Fetal Origin of Hypercholesterolemia.- Chapter 15. Fetal Origin of Osteoporosis.- Chapter 16. Fetal Origin of Osteoarthritis.- Chapter 17. Fetal Origin of Glomerulosclerosis.- Chapter 18. Fetal Origin of Epilepsy.- Chapter 19. Fetal Origin of Testicular Dysplasia.- Chapter 20. Fetal Origin of Premature Ovarian Insufficiency.- Chapter 21. Methods of In vivo and In vitro Study of Fetal-originated Disease.- Chapter 22. Targets for Early Warning and Drug Intervention for Fetal-originated Disease.