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Full Description
This book covers advanced and up-to-date analyses of the synthesis, fragmentation, and dysregulation of Small Leucine-Rich Proteoglycans (SLRPs) in some common matrix-related diseases. These SLRPs act as autonomous triggers of inflammation in conditions such as cancer, cartilage tissue degeneration, renal (kidney) diseases, as well as skin, tendon, musculoskeletal, and craniofacial tissues, responding to stress, injury, and impairment of normal function.
Chapters describe the significance behind the formation of proteolytic molecular fragments of SLRPs and why they alter inflammatory cell-signaling pathways, acting as Damage-Associated Molecular Patterns (DAMPs), that can function as Pathogen-Associated Molecular Patterns (PAMPs) in the early, intermediate, and advanced stages of matrix dysregulation and diseases. It also discusses evidence-based therapeutic approaches useful for identifying molecular fragments as potential biomarkers of matrix degeneration, providing a thorough understanding on the regulatory role of SLRPs in matrix homeostasis and diseases. The book is supplemented with well-illustrated figures, tabulated analysis, and critical review questions for further investigations that identifies gap in current understanding.
The book is relevant for experts in medical sciences specializing in cell, extracellular matrix-based tissue analysis, researchers, as well as students interested in investigating matrix-related changes during the pathological progression of diseases.
Contents
Ch 1 The family, structure, and functions of small leucine rich proteoglycans (SLRPs).-Ch 2 Diseases of the matrix and the role of SLRPs in inflammatory catabolism.- Ch 3 Regulatory role and significance of class I SLRPs: Biglycan, Decorin and Asporin.- Ch 4 Regulatory role and significance of Class II SLRP's: Fibromodulin, Lumican, Osteoadherin, PRELP, and keratocan.- Ch 5 Regulatory role and significance of Class III SLRPs: Osteoglycin, Epiphycan and Opticin.- Ch 6 Regulatory role and significance of Class IV SLRPs: Tsukushi, Chondroadherin and Nyctalopin.- Ch 7 Regulatory role and significance of Class V SLRPs: Podocan and Podocan-like protein-1.- Ch 8 Biological basis behind molecular fragmentation of SLRPs as DAMPs.- Ch 9 SLRPs and its therapeutic relevance.- Ch 10: Critical conclusive overview: SLRPs as DAMPs.
