Neuroinflammation and Autophagy in Neurodegeneration : Mechanistic Insights into Cellular Biology and Advanced Multimodal Therapeutics

Khanal, Pukar (EDT)/ Patil, B. M. (EDT)/ Chikhale, Rupesh (EDT)

Springer Verlag, Singapore（2025/12発売）

• 製本 Hardcover:ハードカバー版／ページ数 262 p.
• 言語 ENG
• 商品コード 9789819539444

Full Description

This book explores the complex interplay between neuroinflammation and autophagy, offering a comprehensive understanding of how these processes drive the development and progression of neurodegenerative diseases. It establishes how chronic inflammation not only disrupts autophagy but also creates feedback loops that exacerbate cellular dysfunction and accelerate neurodegeneration.

The book's core focus is on presenting biological processes at the cellular level, such as neuronal function, glial activation, and protein aggregation in multiple metabolic brain diseases. It discusses key pathways such as mTOR, AMPK, and inflammasomes that directly affect neuronal function. It contains dedicated chapters on Alzheimer's, Parkinson's, ALS, Huntington's, and Multiple Sclerosis, offering disease-specific insights and tailored discussions for each condition. The book complements these mechanistic insights with therapeutic strategies, lifestyle interventions, and emerging trends in biomarkers and personalized medicine. It highlights emerging treatments, repurposed anti-inflammatory drugs, and the neuroprotective property of diet and microbiome. Thus, this book establishes a multidisciplinary perspective combining insights from neuroscience, molecular biology, immunology, and pathology to provide a well-rounded understanding of neurodegenerative mechanisms and therapies. 

The emphasis on dual-pathway modulation and the holistic perspective in the book makes it an essential resource for researchers, clinicians, and healthcare professionals in neurology and neurobiology who seek a comprehensive understanding of neurodegenerative disease mechanisms. Graduate and advanced undergraduate students in neuroscience will also benefit from the detailed exploration of cellular pathways and therapeutic strategies.

Contents

Part I: Neuroinflammation and Autophagy in Neurodegenerative Disease
.- Chapter 1: Neuroinflammation and Its Impact on Autophagy in Neurodegeneration 
.- Chapter 2: Mechanisms of Autophagy and Its Dysregulation in Neurodegenerative Diseases 
.- Chapter 3: Glial Cells, Cytokines, and Inflammasomes in Neurodegeneration 
.- Chapter 4: Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and Their Role in Neurodegeneration
.- Chapter 5: Protein Aggregation, Oxidative Stress, and Autophagic Dysfunction in Neurodegenerative Diseases    
.- Chapter 6: Blood-Brain Barrier Dysfunction in Neuroinflammation and Autophagy  
.- Chapter 7: Epigenetic Regulations of Neuroinflammatory and Autophagic Pathways 

Part II: Neurodegenerative Diseases and Mechanistic Insights
.- Chapter 8: Autophagy and Neuroinflammatory Pathways in Alzheimer's Disease  
.- Chapter 9: Inflammation and Autophagic Dysfunction in Parkinson's disease 
.- Chapter 10:Glial Activation and Autophagic Imbalance in Amyotrophic Lateral Sclerosis 
.- Chapter 11:Protein Aggregation and Neuroinflammation in Huntington's Disease 
.- Chapter 12:Inflammatory Demyelination and Autophagic Dysfunction in Multiple Sclerosis
.- Chapter 13:Disrupted Cellular Clearance and Inflammatory Loops in Frontotemporal Dementia

Part III: Therapeutic Strategies and Emerging Research    
.- Chapter 14:Neuroinflammation and Autophagy in Neurodegenerative Therapy
.- Chapter 15:Advanced Delivery Systems and Gene Editing in Neurotherapeutics
.- Chapter 16:Lifestyle, Diet, and the Gut-Brain Axis in Neuroprotection   
.- Chapter 17:Biomarkers to Personalized Therapies in Neurodegenerative Medicine.