Full Description
This contributed volume provides a comprehensive overview of CAR T-cell therapy, focusing on its application in solid tumors, an area where treatment success has been more elusive. While CAR T-cell therapy has revolutionized the treatment of hematologic malignancies, its potential in solid tumors remains a frontier of intense research and development. This volume bridges the knowledge gap by addressing both the successes and challenges faced by researchers and clinicians in this evolving field.
The chapters cover topics such as the design of next-generation CAR T-cells, novel targets for solid tumors, and the integration of CAR T-cell therapy with other immunotherapeutic strategies. Readers will discover cutting-edge techniques like CRISPR-mediated gene editing, bispecific CARs, and synthetic biology. The book also explores critical questions about manufacturing challenges, regulatory hurdles, and clinical trial outcomes, providing a holistic view of CAR T-cell therapy. Contributions from leading experts in oncology, immunology, and molecular biology offer a multidisciplinary perspective, making this book a valuable resource for understanding the molecular and clinical dynamics of CAR T-cell therapy.
This book is designed for a diverse audience, including researchers, clinicians, and industry professionals involved in cancer research, immunotherapy, and clinical applications. It is also a key reference for graduate and postgraduate students in fields like oncology, immunology, and biotechnology. By offering a comprehensive analysis of the technical, clinical, and regulatory aspects of CAR T-cell therapy, this book serves as a critical resource in the advancement of cancer treatment.
Contents
Chapter 1: History and Evolution of CAR T-Cell Therapy.- Chapter 2: CAR T-Cell Therapy: Basic Principles and Mechanisms.- Chapter 3: Targeting Tumor-Specific Antigens: Overcoming Antigen Escape and Tumor Heterogeneity.- Chapter 4: Engineering CAR T-Cells: Advances in Vector Design and Gene Editing.- Chapter 5: Optimizing CAR T-Cell Efficacy: Enhancing Proliferation, Persistence, and Memory.- Chapter 6: Clinical Success of CAR T-Cells in Hematologic Cancers: Lessons from Leukemia and Lymphoma.- Chapter 7: Adverse Effects of CAR T-Cell Therapy and Management: Cytokine Release Syndrome and Neurotoxicity.- Chapter 8: Overcoming Challenges of CAR T-Cell Therapy in Solid Tumor Microenvironments.- Chapter 9: From Bench to Bedside: Innovations and Challenges in CAR-T Cell Therapy Manufacturing and Regulation.- Chapter 10: Novel CAR T-Cell Approaches: Bispecific CARs and TCR-CARs.- Chapter 11: Combining CAR T Cells with Immunotherapies to Enhance Treatment Effectiveness.- Chapter 12: Next-Generation CARs and Beyond: Synthetic Biology and Logic-Gated in Next-Generation CARs.- Chapter 13: Regulatory landscape and challenges in CAR-T cell therapy development and clinical trials.- Chapter 14: Personalized CAR T-Cell Therapy: Tailoring to Patient-Specific Tumors.
