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Full Description
This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.
Contents
Future Strategies for Commercial Biocatalysis. Synthetic Approaches to Inhibitors of Isoprenoid Biosynthesis. Using a Recombinant Metagenomic Lipase for Enantiomeric Separation of Pharmaceutically Important Drug Intermediates. Biotechnological Production of Prenylated Xanthones for Pharmaceutical Use. Chemoenzymatic Approaches Towards (S)-Duloxetine. Synthesis of Antioxidants via Biocatalysis. Biocatalysts: The Different Classes and Applications for Synthesis of APIs. Laccase-Mediated Synthesis of Novel Antibiotics and Amino Acid Derivatives. Hydrolytic Enzymes for the Synthesis of Pharmaceuticals. Ene-Reductases in Pharmaceutical Chemistry. Biocatalyzed Synthesis of Antidiabetic Drugs. Glucose-Sensitive Drug Delivery Systems Based on Phenylboronic Acid for Diabetes Treatment. Synthesis of Important Chiral Building Blocks for Pharmaceuticals Using Lactobacillus and Rhodococcus Alcohol Dehydrogenases. Asymmetric Reduction of C=N Bonds by Imine Reductases and Reductive Aminases. Cipargamin: Biocatalysis in the Discovery and Development of an Antimalarial Drug. Halogenases with Potential Applications for the Synthesis of Halogenated Pharmaceuticals. Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450. Oxyfunctionalization of Pharmaceuticals by Fungal Peroxygenases. Biocatalytic Synthesis of Chiral 1,2,3,4-Tetrahydroquinolines. New Strategies to Discover Non-Ribosomal Peptides as a Source of Antibiotics Molecules. Enzyme Kinetics and Drugs as Enzyme Inhibitors.
