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Full Description
This book provides an actual overview of structure, function, and application of carbohydrate-modifying biocatalysts. Unlike amino acids and nucleic acids, carbohydrates have been disregarded for a long time by the scientific community, mainly due to their complex structure and a lack of suited experimental methods for structure determination. Meanwhile, the situation changed with increasing knowledge about carbohydrates, glycoconjugates, and carbohydrate-modifying enzymes together with the key roles they play in biological processes such as recognition, signal transduction, and immune responses. An outcome of research activities in glycoscience, which, at the same time, is of great general interest, is the development of several new pharmaceuticals against serious diseases such as malaria, cancer, and various storage diseases.
Contents
Basics in Carbohydrate Chemistry. Glycoconjugates: An Overview. Oligosaccharides and Glycoconjugates in Recognition Processes. Glycoside Hydrolases. Disaccharide Phosphorylases: Mechanistic Diversity and Application in Glycosciences. Enzymatic and Chemo-Enzymatic Synthesis of Nucleotide Sugars: Novel Enzymes, Novel Substrates, Novel Products, and Novel Routs. Iteratively Acting Glycosyltransferases. Bacterial Glycosyltransferases Involved in Molecular Mimicry of Mammalian Glycans. Sulfotransferases and Sulfatases: Sulfate Modification of Carbohydrates. Glycosylation in Health and Disease. Sialic Acid Derivatives, Analogs and Mimetics as Biological Probes and Inhibitors of Sialic Acid Recognizing Proteins. Enzymes of the Carbohydrate Metabolism and Catabolism for Chemoenzymatic Syntheses of Complex Oligosaccharides. From Gene to Product — Tailor-Made Oligosaccharides and Polysaccharides by Enzyme and Substrate Engineering. Synthesis and Modification of Carbohydrates via Metabolic Pathway Engineering in Microorganisms. Metabolic Pathway Engineering for Hyaluronic Acid Production. Microbial Rhamnolipids. Chitin-Converting Enzymes: Linear and Cyclic Oligosaccharides. Fungal Degradation of Plant Oligo- and Polysaccharides. Bacterial Strategies for Plant Cell Wall Degradation and Their Genomic Information. Design of Efficient Multi-Enzymatic Reactions for Cellulosic Biomass Processing.
