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Full Description
This book provides an overview of the essential characteristics and clinical applications of therapeutic proteins against human diseases, including cancers, immune disorders, infections, and other diseases. It presents the latest advancements in protein engineering techniques for producing desirable therapeutic proteins. The book also covers the strategies used to formulate and deliver systemic therapeutic proteins, approved protein therapeutics and their targets, and pharmacogenetic biomarkers. Further, it discusses challenges associated with the clinical implications of therapeutic proteins, including safety, immunogenicity, protein stability, degradation, and efficacy. It illustrates the development of biosimilar antibodies, optimization strategies for producing biobetter antibodies, and presents fundamental concepts about biosuperior therapeutics. Lastly, it includes a discussion about protein-based vaccines against bacterial and viral infections.
Contents
Chapter 1_Introduction to Protein Therapeutics..- Chapter 2_Clinical Applications of Protein-based Therapeutics Against Various Diseases..- Chapter 3_Protein Engineering Methods for the Design of Protein Therapeutics.- Chapter 4_Recombinant Production of Therapeutic Proteins.- Chapter 5_Antibodies as Protein Therapeutics.- Chapter 6_Streptokinase: The Success Story of a Therapeutic Protein.- Chapter 7_Strategies for Formulation and Systemic Delivery of Therapeutic Proteins.- Chapter 8_Approved Protein Therapeutics and Their Biochemical Targets.- Chapter 9_Pharmacogenetic Biomarkers of Protein Therapeutics.- Chapter 10_Immunogenicity of Therapeutic Proteins.- Chapter 11_Efficacy and Safety Issues of Therapeutic Proteins.- Chapter 12_Emerging Trends, Challenges, and Opportunities in Protein Therapeutics.- Chapter 13_Biosimilar, Biobetter & Biosuperior Therapeutic Proteins.- Chapter 14_Therapeutic Protein-based Vaccines.
