Full Description
This timely book discusses antimicrobial drug resistance, specifically, the resistance against the beta-lactam class of antibiotics by Gram-Negative bacteria. The book is broadly divided into five sections. The first section describes the underlying mechanisms of antimicrobial resistance in Gram-negative bacteria. It gives an insight into the beta-lactamases, their types, classification, inhibitors, etc. The second section delves deep into the genetic basis of resistance. It talks about transposons, integrons, insertion sequences associated with antibiotic-resistant genes. The next section describes phenotypic and molecular methods to detect beta-lactam resistance. The fourth section talks about the epidemiology and prevalence of beta-lactamases in the environment. The last section of the book describes the various therapeutic options to combat this growing public threat of antimicrobial resistance. It talks about the current reserve drugs, as well as the newer antibiotic agents that are in the pipeline.
This book is essential for clinical practitioners, students, and researchers in basic and medical microbiology.
Contents
Chapter 1. An overview on antibiotic resistance in Gram-negative bacteria.- Chapter 2. Trends in β-lactamases classification.- Chapter 3. Beta-lactamases and their classification: An Overview.- Chapter 4. Class A type beta-lactamases.- Chapter 5. Class B type beta-lactamases: treatment strategies.- Chapter 6. Class C type beta-lactamases (AmpC β- lactamases).- Chapter 7. Class D type β- lactamases.- Chapter 8. Mobile genetic elements.- Chapter 9. Plasmids associated with β- lactamases in bacteria.- Chapter 10. Transposons associated with antibiotic resistance genes in Gram-negative bacteria.- Chapter 11. Integrons and Insertion sequences associated with beta-lactamases.- Chapter 12. Phenotypic methods of detection of β- lactamases- Chapter 13. Molecular methods for detection of β- lactamases.- Chapter 14. Epidemiology and Prevalence of beta-lactamases and recent resistance pattern in Gram-negative bacteria from environmental reservoirs.- Chapter 15. Environmental biofilms as a reservoir of antibiotic resistance and hotspot for genetic exchange in bacteria.- Chapter 16. Beta-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-negative Bacteria.- Chapter 17. Current Reserve drugs.- Chapter 18. Newer Antibiotic agents in pipeline.- Chapter 19. Adjuvant molecules/compounds in combating bacterial resistance.
