Full Description
This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
Contents
Oxidative stress and anti-oxidant strategies in human diseases.- Oxidative stress in the tumorimmune microenvironment.- Oxidative stress-mediated stem cell aging.- Stress proteins: Biological functions, human diseases and virus infections.- Importance of mitochondrial quality controls in Parkinson's disease: the potential interplay of mitochondrial unfolded protein response and mitophagy.- Autophagy in cellular stress responses.- Cysteine metabolism in cancer progression and therapy resistance.- Stress and circadians.- ROS, glucose and lipid metabolism.- Drug repurposing: An avenue towards stress medicine in cancer therapy.- Redox regulation of metabolic enzymes in cancer.- Stress and inflammation.- Oxidative stress in cell signaling and cell fate determination under glucose starvation.
