Full Description
This book provides acomprehensive overview of cell signalling pathways and morphogens in the genesis of brain tumours. It also explains the role of brain tumour stem cells in the brain tumour progression. It also elucidates the novel early biomarkers that can be utilized to diagnose brain tumours. It presents the basic developmental pathways and morphogens, including retinoic acid and TGF-b that promote brain tumorigenesis. The chapters illustrate the role of stem cells and stem cells mediated cell signalling pathways including, Sonic hedgehog, Notch, Wnt in the brain tumour growth. The chapters also emphasize the role of transcription factors, mainlyNanog, Sox, BMI1, HIF1 and Pax6 in the brain tumouriogensis. It highlights the role of NF-kb, Myc and neurotrophins in the brain tumour development. Finally, the book summarizes the potential early therapeutic targets and targeted drug discovery for brain tumours.
Contents
Introduction of Cell signalling Pathways and Brain Tumours.- Wnt cell signalling pathway and brain tumours development.- Notch cell signalling pathway and Brain Tumours.- Shh cell signalling pathway and paediatric brain tumour "Medulloblastoma".- Role of Shh cell signalling pathway in "glioma".- Role of stem cell marker NANOG in brain tumours development.- Stem cell factor Sox2 and Brain Tumours Development.- Role of Neurotrophins in brain tumor development.- Role of NFkβ in brain tumour development.- Role of Myc in brain tumours development.- Role of P53 in Medulloblastoma Development.- Role of Gene TP53 in glioblastoma development.- Role of HIF-1 in Brain Tumour Development.- EGFR and its role in glioma development.- Role of EFGR in medulloblastoma development.- Role of OCT4 in glioblastoma development.- Role of OCT4 in paediatric brain tumour "medulloblastoma" development.- Role of Mitogen activated protein (MAP) Kinase in paediatric brain tumour "medulloblastoma"
