Full Description
Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries.
This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.
Contents
Chapter 1. Plant-Derived Drug Discovery: Introduction to Recent Approaches.- Chapter 2. Herbal Medicines as a Rational Alternative for Treatment of Human Diseases.- Chapter 3. Effect of Natural Products on Improvement of Blood Pathophysiology for Management of Sickle Cell Anemia.- Chapter 4. Anti-Inflammatory Activity of Medicinal Plants: Present Status and Future Perspectives.- Chapter 5. Cannabinoids as Promising Anti-Inflammatory Agent.- Chapter 6. Plant Volatile Organic Compounds and Neuro-Regenerative Health.- Chapter 7. Medicinal Plants and their Role in Inflammation: A Close Look on Future Drug Discovery.- Chapter 8. Phytochemistry and Pharmacological Activities of Rhodiola imbricata Edgew., a High Value Medicinal Herb of Cold Desert Himalaya.- Chapter 9. Phyllanthus amarus Schum. & Thonn. as Herbal Medicine: Ethnobotany, Phytochemistry and Pharmacology Aspects.- Chapter 10. Medicinal Applications of Cannabidiol from Genus Cannabis L.- Chapter 11. Genetic Variability in Ocimum L. Germplasm, Medicinal and Economic Potential for Value Addition and Product Development.- Chapter 12. Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb.- Chapter 13. Chemical Constituents and Pharmacological Activities of Marrubium vulgare L., an Important Medicinal Herb.- Chapter 14. Medicinal Value of High Altitude Plants of Indian Himalaya.- Chapter 15. Medicinal Plants of District Kupwara Used in Treatment of Human Diseases and Associated Biological Functions.- Chapter 16. Capsicum chinense Jacq.: Ethnobotany, Bioactivity and Future Prospects.- Chapter 17. Indigenous Plants Knowledge for Human Health Care from Jasrota Wildlife Sanctuary (Western Himalaya), India.- Chapter 18. Ethanobotany and Phytochemistry of Lantana camara L. (Verbenaceae).- Chapter 19. Cymbopogon winterianus Jowitt ex Bor, a Hub for Various Industrial and Pharmaceutical Applications.- Chapter 20. Botanical Sources, Chemistry and Biological Functionsof Berberine: A Critical Review.
