Full Description
This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on recently identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
Contents
Architecture of the vessel wall.- Ultrastructure of vascular smooth muscle.- Vascular endothelium.- Electrical and mechanical properties of vascular smooth muscle.- Biochemistry of the contractile proteins of smooth muscle.- Metabolism of vascular smooth muscle.- Neurotransmitters.- Endothelium-derived factors.- Local metabolic factors.- Shear stress myogenic response and blood flow autoregulation.- Intracellular Ca2+ regulation.- Regulation of myosin light chain phosphorylation.- Cyclic AMP signalling.- Cyclic GMP signaling.- Coronary vasoreactivity.- Cerebral vasoreactivity.- Pulmonary vasoreactivity.- Hypoxic vasoreactivity.- Ageing and vasoreactivity.
