Full Description
The pathogenesis of cell death and necrosis in the liver is a central topic of research in liver disease. A molecular understanding of events and sequences leading to cellular death provides the basis for preventive and therapeutic efforts. This volume originates from a "Workshop on Experimental Liver Injury" held on November 9 and 10, 1974, in Freiburg, Germany. Recent progress in the elucidation of the mode of action includes agents inducing liver cell necrosis by a primary dis- turbance of nucleotide and nucleic acid metabolism as well as hepa- totoxins characterized by a primary attack on cellular membranes. I hope that this book will contribute to an increasing understanding of disease mechanisms. Freiburg im Breisgau Dietrich Keppler June 1975 Acknowledgments The generous support from Dr. H. Falk, Freiburg, has been a prereqUIsite for the organisation and publication of the meeting on "Pathogenesis and Mechanisms of Liver Cell Necrosis". I wish to express my sincere thanks for this sponsorship. I am indebted to those who acted as chairmen during the meeting: Professors H. Remmer (Tilbingen), M. Frimmer (Giessen), W. Gerok (Freiburg), H. Popper (New York), H.
Schimassek (Heidelberg), and K. Decker (Freiburg).
Contents
I Morphology of Liver Cell Necrosis.- 2 Morphologic Features of Hepatocellular Necrosis in Human Disease.- 3 Hydrolases and Cellular Death.- 4 Macromolecular Syntheses and the Maintenance of Liver Cell Integrity.- 5 Quantitative Aspects of Biochemical Mechanisms Leading to Cell Death.- 6 Pathogenesis of Hepatic Necrosis Caused by Amanitin-Albumin Conjugate.- 7 Amanitin Poisoning in the Dog.- 8 Pathogenesis of Frog Virus 3 Induced Hepatitis in Mice.- 9 Consequences of Uridine Triphosphate Deficiency in Liver and Hepatoma Cells.- 10 Ribosomes in Dying Liver Cells.- 11 Histotopochemistry of Glycogen and Glycogen Enzymes After Allyl Formate Poisoning.- 12 The Measurement of Liver Injury and Protection, with Special Reference to Paracetamol, Dimethylnitrosamine and Carbon Tetrachloride.- 13 Hepatoprotective Substances: A Partial Assessment.- 14 Liver Morphology and Enzyme Release: Further Studies in the Isolated Perfused Rat Liver.- 15 Phalloidin, A Membrane Specific Toxin.- 16 Morphological Changes Induced by Phalloidin in the Rat Liver.- 17 Interaction of Phalloidin with Actin.- 18 Mechanism of Necrosis Induced by Hepatotoxic Bile Acids.- 19 The Role of Lipid Peroxidation in Liver Injury.- 20 Inhibition of Protein Synthesis in Carbon Tetrachloride-Induced Liver Injury.- 21 Mechanism of Hepatic Necrosis Induced by Halogenated Aromatic Hydrocarbons.
