Full Description
This volume is based upon presentations made to the 4th European Symposium on Radiopharmacology which was held under the auspices of the European Joint Committee on Radiopharma- ceuticals (ENMS / SNME) in Athens from March 28 - 31, 1984. The Medical Insurance Foundation of the National Bank of Greece (TYPET) sponsored this meeting and the Joint Committee would like to express their gratitude to the local organising committee: G. Limouris, M. Pierroutsakou, A. Sarris, A. Tzoulis and C. Binas. A word of thanks also to Mrs. Tineke Busker who prepared the camera ready copy. The meeting reflects the continuing and growing interest in biodistribution and factors which can influence bio- distribution in the clinical situation. The choice of sub- jects, respiration, cerebral function, biodistribution and metabolism complement earlier volumes in this series and reflect European interests in these areas. P. H. Cox Rotterdam, April 1985 VII CONTENTS Foreword P. H. Cox v Contributors XI I. THE RESPIRATORY SYSTEM Physiology and pathophysiology of the respiratory system J. Roth, E. Henze, W. E. Adam 3 Generator-produced Krypton-81m in gas and liquid phases for medical applications M.
Guillaume, N. Garzaniti, H. Zicot, T. Khuc, P. Bartsch 23 Noble radionuclides for lung ventila- tion studies I. Bofilias 49 Radioaerosols in nuclear medicine M. Pillay, B. Shapiro, P. H. Cox 57 99m A dry aerosol of Tc -albuminmilli- micro spheres for lung ventilation scintigraphy: preparation, inhalation apparatus and examples of clinical results P. Angelberger, I. Zolle, A. Strigl, H. Kahn, A. Mostbeck, W.
Contents
I. The Respiratory System.- Physiology and pathophysiology of the respiratory system.- Generator-produced Krypton-81m in gas and liquid phases for medical applications.- Noble radionuclides for lung ventilation studies.- Radioaerosols in nuclear medicine.- A dry aerosol of Tc99m-albuminmilli-microspheres for lung ventilation scintigraphy: preparation, inhalation apparatus and examples of clinical results.- II. Cerebral Function.- New agents for probing glucose turnover and receptor densities in the brain.- Cerebral uptake of radioiodinated amphetamines — basic research and clinical results.- Radiolabelled Schiff bases in brain studies.- III. Biodistribution and Metabolism of Radiopharmaceuticals.- Some recent progress in the development and application of radiopharmaceuticals labelled with 11C and 18F.- Radiopharmaceuticals suitable for cardiac emergency studies.- The pharmacokinetics of Tc99m-diethyl ida in hyperferremic mice.- Subcellular distribution of Tc99m Sn-phytate in the liver of rats.- Treatment of thyroid disorders by 131I.- IV. Extraneous Factors Affecting Biodistribution.- Alterations in the biodistribution of radiopharmaceuticals, caused by extraneous influences.- The effects of drugs and therapeutic procedures on the biodistribution of skeletal reagents.- Interaction between some disinfectants and Tc99m-radiopharmaceuticals.- Altered uptake of Tc99m-MDP, Ca47 and Ga67 by mice osteogenic sarcoma after administration of a cytostatic drug.- Visualisation of gallbladder and gut on Tc99m bone scintiscans.- Drug-free high-quality tumour imaging with 67Ga.- Author index.
