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Full Description
th The 16 Jerusalem Symposium debated on one of the most im- portant subjects of modern molecular biology: the nucleic acids. It continued the tradition of gathering the most distinguished experts in the field. Placed under the auspices of the Isra‾l Acade‾y of Sciences and Humanities and the Hebrew University of Jerusalem it was sponsored by the Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild) of Paris and the Na‾ional Foundation for Cancer Research of Bethesda, U. S. A. We wish to express our deep thanks to the Baron Edmond de Rothschild for his continuous generosity which guarantees the perenniality of these meetings and to the authorities of the National Foundation for Cancer Research, in particular Mrs Tamara Salisbury and Dr. Franklin Salisbury for having joined hands with us in this venture. We wish also to express our gra‾itude to the adminis- trative staff of the Isra‾l Academy and in particular to Mrs Avigail Hyam for the efficiency and excellency of the local arrangements. Bernard Pullman ,Joshua Jortner B. Pullman and J. Jortner (eds. ) , ,Vucleic Acids the Vectors of Life, /-/5. (c) 1983 by D. Reidel PuhlisliinK Company. BASE SEQUENCE. I-!E.
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Contents
Base Sequence, Helix Structure and Intrinsic Information Readout in DNA.- New Wrinkles on DNA.- X-Ray Analysis of Oligonucleotides and the Changing Concept of DNA Structure.- Dynamic Structure of Z-DNA.- Relative Stability of B and Z Structures in Oligodeoxynucleotides with Different Alternating Base Sequence and Length.- Electrostatic Molecular Potential versus Field in Nucleic Acids and their Constituents.- Probin for and with Left-handed DNA: Poly [d(A-br5C).d(G-T)], A Member of a New Family of Z-Forming DNAs.- Structures of DNA: A Case Study of Right and Left Handed Duplex in the B-Form.- Two Dimensional NMR Investigation of the Structural Properties of DNAS.- Secondary Structure of DNA in Solution by NMR Methods.- Dependence of Oligonucleotide Conformational Properties on Sugar Ring and Base-sequence. 1H and 13C. N.M.R. Studies.- Conformational Flexibility of Nuclei Acids.- 31P NMR Studies on the Structure and Dynamics of DNA in Hydrated Fibers.- Nucleic Acid Junctions: The Tensors of Life?.- NMR Studies on Short Helices.- Theoretical Probes of Nucleic Acid Conformation.- A Novel Conformational Equivalence between the Heminucleotide Blocks of the Nucleotide Repeat. Its Implications in Conformation Analysis of Nucleic Acids.- Presence of Nonlinear Excitations in DNA Structure and Their Relationship to DNA Premelting and to Drug Intercalation.- Ribonuclease T1: Mechanism of Specific Guanine Recognition and RNA Hydrolysis.- DNA Bending and Protein-DNA Interactions.- Dynamics and Specificity of Protein-nucleic Acid Interactions in Model Systems.- The recA Gene Product from E. coli. Binding to Single-stranded and Double-stranded DNA.- Fluorescence Decay Studies of Peptide-nucleic Acid Complexes.- Alteration of the B Form of DNA by Basic Peptides.- The Interaction of Certain Nucleic Acids with Proteins and Metal Ions in Solution.- Chromatin Higher Order Structure and Gene Exoression.- Protein-nucleic Acid interaction: The Aminoacvlation of T-RNA and its Evolutionary Aspect.- Conformation of DNA, The Nucleosome and Chromatin. Hydration of DNA.- Nucleosomal DNA Structure.- Sequence and Secondary Structure Conservation in Ribosomal RNAs in the Course of Evolution.- The Versatile Transfer RNA Molecule: Crystallography of Yeast tRNAAsp.- Solution Conformation of tRNAs: Correlation with Crystal Structures.- NMR Studies of the Structure of Yeast tRNAPhe in Solution and of its Complex with the Elongation Factor Tu from B. Stearothermophilus.- Electronic Interactions in RNA Constituents and their Effects on Helical Conformations.- Correlated Internal Motions in Left-handed DNA Double Helices: Z-B Transition Driven by Drug Binding.- The Binding of the Carcinostatic Drugs Cis-[Pt(NH3)2Cl2] and [Ru(NH3)5Cl]Cl2 with Yeast Transfer RNAPhe. Absence of Binding to Watson-Crick Base Pairs.- Structures and Mechanisms of Mispairing in a Helical Environment Including Sequence Effect.- Drug Nucleic Acid Interactions: Proflavine Intercalation into Doublehelical Fragments of RNA and DNA.- Consequences of Substituting 2NH2A for A in Synthetic DNA'S.- Nonionic Oligonucleotide Analogs as new Tools for Studies on the Structure and Function of Nucleic Acids Inside Living Cells.- Solution Conformational Characteristics of Chemically Modified Purine (?) Pentosides.- Deoxyribonucleotide Biosynthesis: A Critical Process for Life.- IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN) Abbrevations and Symbols for the Description of Conformations of Polynucleotide Chains.- Index of Subjects.
