Full Description
This book is a comprehensive guide to the diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns.
Divided into eight sections, the text begins with detailed discussion on foetal haematology, antenatal diagnosis of disorders, red blood cell disorders and anaemia in the newborn, and coagulation and platelet conditions.
The following chapters cover foetal and neonatal malignancies and blood transfusion, followed by a final section on immunological disorders.
Each topic explains new advances, all current treatment protocols, new drugs, and management approaches.
Chapters are further enhanced by clinical images and tables.
Key points
Comprehensive guide to diagnosis and treatment of blood and immunological disorders and cancer in foetuses and newborns
Presented in an easy to follow format, explaining new advances, treatment protocols, new drugs, and management approaches
Includes discussion on neonatal malignancies and blood transfusion
Highly illustrated with clinical images and tables
Contents
Section 1: Fetal Hematology and Antenatal Diagnosis of Hematological Disorders
Physiology of Hematopoiesis
Developmental Hemostasis and Physiology ofHemostasis in the Fetus and the Newborn
Granulocytes: Development and Physiology
Developmental Aspects of Platelets
Fetal Anemia
Thalassemia in the Fetus: Prenatal Diagnosis
Genetic Counseling for Hematological Disorders
Fetal Hematological Disorders: Future Ahead
Section 2: RBC Disorders and Anemia in Newborn
Developmental Erythropoiesis
Normal Hematological Values and Variation in Newborn Periodwith Special Reference to Hb and RBC Parameters
Effect of Nutritional Deficiency Anemia duringPregnancy on Fetus and Newborn
Anemia of Prematurity
Clinical Aspect of Immune Hemolytic Disease of Newborn
Laboratory Management of ABO and Rh HemolyticDisease of the Fetus and Newborn
Nonimmune Hemolytic Anemia
Inherited Bone Marrow Failure Syndromes
Polycythemia and Hyperviscosity Syndrome in Newborn
Section 3: Coagulation Disorders in Newborn
Congenital Coagulation Disorders in the Neonate
Vitamin K Deficiency Bleeding
Disseminated Intravascular Coagulation in the Neonatal Period
Thrombophilia in Newborns
Section 4: Platelets, Platelet Disorders and Approach to Bleeding in Newborn
Approach to Neonatal Thrombocytopenia
Neonatal Thrombocytopenia: Syndromic Causes
Qualitative Platelet Disorders
Approach to a Bleeding Neonate
Section 5: Neutrophil Disorders
Neutrophilia
Important Causes of Neutropenia Including Inherited Conditions:Diagnosis and Work-up
Neutrophil Function Defects
Management of Neutropenia and Infections
Section 6: Fetal and Neonatal Malignancy
Cancers in Infants
Neonatal Leukemia
Neonatal Liver Tumor
Neuroblastoma
Renal Tumors in Neonates
Neonatal Soft Tissue Sarcomas
Fetal and Neonatal Germ Cell Tumors
Retinoblastoma and its Prenatal Screening
Pharmacology of Anticancer Drugs in Neonate
Challenges in Neonatal Malignancies
Section 7: Blood Transfusion (Component Therapy) and Supportive Therapy
Cellular Blood Components in Neonatal Practice
Plasma and Its Derivatives
Technical Aspects of Blood and Blood Components Transfusion including Leukodepletion and Irradiation
Risk of Transfusion in Fetus and Neonate
Hematological Growth Factors as Supportive Therapy
Section 8: Immunological Disorders
Introduction to Immunology
Fetal and Neonatal Immunity
Infections in Neonatal Period: Primary Immunodeficiency Perspective
Approach to Newborns with Immunodeficiency
Neutrophil Functions and Disorders of Neutrophils in Newborns
Combined T- and B-Cell Defects
Primary Antibody Deficiencies
Combined Immunodeficiencies with Associated or Syndromic Features
Immune Dysregulation Syndromes
Complement Disorders
Autoinflammatory Syndromes
Management of Specific Immunodeficiencies
Neonatal Screening and Prenatal Diagnosis of Primary Immunodeficiency Disorders
Index
