Full Description
Despite guidelines published by the European Society for Human Reproduction, the American Society of Reproductive Medicine, the Royal College of Obstetricians and Gynaecologists, and many other national bodies, the field of recurrent pregnancy loss (RPL) remains full of controversy. From its definition, two versus three miscarriages, consecutive versus non-consecutive, there is little consensus between guidelines.
RPL is a multi-specialty field encompassing obstetricians, gynaecologists, specialists in ART (assisted reproductive technology), endoscopists, endocrinologists, and rheumatologists. Research in the field is limited by the fact that the number of patients affected by RPL is small, and when further divided by different aetiological factors, each centre deals with a small number of patients.
This book is a comprehensive guide to RPL for obstetricians, gynaecologists, ART specialists, and trainees.
The fourth edition has been thoroughly revised to provide clinicians with the latest advances in the field. Extensive new research has led to the addition of 13 new chapters which include diagnostic recommendations from the various national societies and colleges.
Access to three complimentary videos is included with this invaluable resource.
The previous edition (9789352700912) published in 2018.
Contents
1. History, Overview, and Terminology
2. Genetic Evaluation of Products of Conception
3. Monogenic Factors
4. Parental Genetic Testing
5. Epigenetic Factors
6. Cell-free Fetal DNA Testing
7. Male Factors
8. Y Chromosome Microdeletions
9. Male Microbiome, Genetic, and Epigenetic Factors
10. Preimplantation Genetic Screening
11. Hysteroembryoscopy
12. Chronic Endometritis
13. Latent Tuberculosis
14. Cytokines: Success or Failure of Pregnancy
15. Uterine Natural Killer Cells
16. Endometrial Microbiome
17. Endometriosis
18. Adenomyosis
19. Congenital Uterine Malformations
20. Intrauterine Pathologies
21. Arteriovenous Malformations
22. Cervical Insufficiency
23. Role of Laparoscopy
24. Interpregnancy Imaging
25. Ultrasound Evaluation of Endometrium
26. Antiphospholipid Syndrome
27. Autoimmune Diseases
28. Inherited Thrombophilia
29. Thromboelastography
30. Thyroid Disorders
31. Polycystic Ovarian Syndrome
32. Insulin Resistance and Metabolic Syndrome
33. Diminished Ovarian Reserve
34. Hyperhomocysteinemia
35. Role of Vitamin D
36. Obesity
37. Environmental Factors
38. Recurrent Biochemical Pregnancy
39. Recurrent Molar Pregnancies
40. Recurrent Ectopic Pregnancy
41. Role of Natural Micronized Progesterone
42. Role of Dydrogesterone
43. Assisted Reproductive Technology
44. Intravenous Immunoglobulins
45. Evidence for Intravenous Immunoglobulin Use in Recurrent Pregnancy Loss
46. Lipid Emulsion Therapy
47. Role of Human Chorionic Gonadotropin
48. Role of Granulocyte Colony-stimulating Factor
49. Role of Lymphocyte Immunotherapy
50. Role of Micronutrients and Antioxidants
51. Role of Stem Cells for Ovarian Rejuvenation
52. Role of Stem Cells for Endometrial Rejuvenation
53. Tender Loving Care and Reassurance Scans
54. Hysteroscopic Evacuation of the Uterus
55. Placental Pathology
56. Grief Counseling
57. Medicolegal Implications
58. Resurgence of Statins in Recurrent Pregnancy Loss
59. Role of Surrogacy
60. Role of Artificial Intelligence
