Full Description
Incretins are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from cells in the pancreas after eating. Incretin based drugs are used to control blood sugar levels in the management of diabetes.
This book is a concise guide to incretin based therapy. Beginning with an introduction to the history and physiology of incretins, the following sections examine the clinical pharmacology of GLP-1 Analogues and DPP-4 Inhibitors, the pleiotrophic effects of incretins and comparative pharmacology.
Each section integrates science with practical therapeutic guidance for clinicians involved in the management of diabetes. The final chapter discusses the future of incretin therapies, including non-diabetic usage and combination therapy.
Key Features
Concise overview of incretin based therapy for the management of diabetes
Guides clinicians step by step through the history and pharmacology of various molecules
Integrates science with practical therapeutic guidance
Includes chapter on the future of incretin therapy
Contents
Section 1: Incretins: An Introduction
History of Incretins
Physiology of Incretins
Incretins Hormones: Effects beyond Glycemic Control
Section 2: Clinical Pharmacology of GLP-1 Analogues
GLP-1 Analogues: An Overview
GLP-1 Analogues: Monotherapy
GLP-1 Analogues: Combination Therapy
GLP-1 Analogues and Insulin Combination
Section 3: Clinical Pharmacology of DPP-4 Inhibitors
DPP-4 Inhibitors: An Overview
DPP-4 Inhibitors: Monotherapy
DPP-4 Inhibitors: Combination therapy
Section 4: Pleiotropic Effects of Incretins
Cardiovascular Effects of Incretins
Neurological Effects of Incretins
Gastrointestinal and Hepatobiliary Effects of Incretins
Incretins and Insulin Sensitivity
Incretins and Obesity
Section 5: Comparative Pharmacology
GLP-1 Analogues vs. DPP-4 Inhibitors
Choosing a GLP-1 Analogue
Choosing a DPP-4 Inhibitor
The Future of Incretin Therapies
