Full Description
The study of stem cell biology is under intensive investigation. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell and gene therapy.
The aim of this book is to provide readers and researchers with timely and accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on conferences given by recognized scientists involved in the international master course on stem cell biology at Sorbonne Université in Paris.
Contents
Preface. Pierre Charbord and Charles Durand.
1) General concepts
Stem cell concepts. Charles Durand and Pierre Charbord.
Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld.
Repair of DNA double-strand breaks in adult stem cells. Leyla Vahidi Ferdousi, Haser Hasan Sutcu and Miria Ricchetti.
Haematopoietic stem cell niches in the bone marrow. Claire Fielding and Simon Mendez-Ferrer.
Computational models of spatio-temporal stem cell organization. Torsten Thalheim and Joerg Galle.
Omics investigations. Christophe Desterke.
2) Pluripotent stem cells and regeneration
The regulatory network of X chromosome inactivation. Jeffrey Boeren, Sabina Jasarevic and Joost Gribnau.
Pluripotent stem cells : a common evolutionary origin ? Guillaume Balavoine.
Directed differentiation of human-induced pluripotent stem cells into hepatic cells: a transposable example of disease modeling and regenerative medicine applications. Antonietta Messina, Eleanor Luce and Anne Dubart-Kupperschmitt.
Hydra and stem cell evolution. Alexander Klimovich and Thomas Bosch.
Regeneration in amniotic vertebrates. Prayag Murawala and Dunja Knapp.
Stem cells and regeneration in plants. Marco Da Costa and Philippe Rech.
3) Adult stem cells
Hematopoietic development in vertebrates. Hanane Khoury, Thierry Jaffredo and Laurent Yvernogeau
Developmental biology of hematopoietic stem cells: Non-cell autonomous mechanisms. Leslie Nitsche and Katrin Ottersbach.
Biology of hematopoietic stem cells in the adult. Rima Haddad, Francoise Pflumio and Marie-Laure Arcangeli.
Epithelial stem cells in the skin. Romain Fontaine, Benedicte Oules, Mathieu Castela and Selim Aractingi.
Mammary stem cells. Silvia Fre.
Intestinal stem cells. Aline Stedman.
Neural stem cells: adult and regenerative aspects. Nathalie Kubis and Martin Catala.
Bone marrow mesenchymal stem cells: from stemness to stromal property of hematopoietic support. Pierre Charbord.
Dental stem cells. Anne-Margaux Collignon, Caroline Gorin, Catherine Chaussain and Anne Poliard.
Stem cells and retina: from regeneration to cell therapy. Olivier Goureau, Giuliana Gagliardi and Gael Orieux.
4) Stem cell-related diseases and therapy using stem cells
Leukemic stem cells. Pierre Hirsch and François Delhommeau.
Glioblastoma stem cells. Nathalie Magne, Sandra E Joppe, Franck Bielle and Emmanuelle Huillard.
Cardiac tissue engineering for repair and regeneration of the heart. Pierre Joanne and Onnik Agbulut.
Stem cells for red blood cell production. Laurence Guyonneau-Harmand and Helene Lapillone.
Hematopoietic stem cells, gene and cell therapy. Emmanuelle Six and Isabelle Andre-Schmutz.
Prospectives for therapy with stem cells in skeletal muscular diseases. Elisa Negroni, Gillian Butler-Browne and Vincent Mouly.
5) Reglementary and philosophical aspects
Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Samuel Arrabal.
Stem cell conceptual clarifications. Lucie Laplane.
Future outlook. Olivera Miladinovic, Pierre Charbord and Charles Durand.
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