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Full Description
In the amazing advancement of process biotechnology, the pressing need of the current millennium is to exploit biological processes. In order to do this various fundamental aspects of process biotechnology need to be understood adequately. This book in its third edition is intended for teaching senior or graduate level courses, and as a self-study text for practising biochemical engineers, biotechnologists, applied and industrial microbiologists, cell biologists, scientists involved in bioprocessing research and development and other related fields. It continues to give intensive quantitative training in the industrial practical applications of the principles of biosystems, and finding the solution of bioprocessing problems.
The book has the following unique features:
Integration of academic and practical bioprocessing principles towards process biotechnology development.
Research generated data never before published in a single collated text.
Detailed aspects of oxygen mass transfer in biological systems.
Ways to control undesirable microorganisms.
Provides scope for progressive development in scale up of industrial bioprocessing system.
Systematic design engineering calculations of bioprocessing systems.
Abundance of illustrative tables, figures and mathematical relations.
Numerous mathematical problems and multiple choice questions.
Contents
Introduction: Progress of Process Biotechnology • Knowledge Collation and Expansion • Bridging the Gap: Biosciences Engineering and Technology • Global Impacts and Scenario • Forecasting • References • Engineering Biology of Cells and Molecules they Synthesize: Cell Biology Events • Structural Engineering of DNA in Advancing Bioprocess Engineering • Biomolecular Design Engineering Tools: Properties and Forefront Applications • References • Medium Engineering for Cell Cultivation and Bioreactions: Introduction • Basic Concept in Medium Design Procedure • Design Procedure • Basics of Material Balance • Growth Limiting Nutrient in the Designed Medium • Engineered Medium in Cell Growth and Product Formation • Metabolic Engineering • Bioorganic Reaction Medium Engineering • Novel Media • References • Contamination Free Fluids for Process Biotecnology: Introduction • Contamination Free Air Supply • Few Non-conventional Air Borne Particle Removal Methods • Contamination Free Medium by Sterilization • References • Concerns of Aeration and Mixing/Agitation in Bioprocessing: Introduction • Oxygen Pathways in Cell Cultivations • Volumetric Oxygen Transfer Coefficient (KL a) • Oxygen Transfer Mechanism and Parameters • Resistances to Gas-Liquid Interface and Bulk Mixing • Recent Concept in Oxygen Transfer Pathway • Mixing/Agitation in Biofluids • Development in Physical Concepts in Liquid Phase Oxygen Transfer Coefficient (KL1) • Advances in Oxygen Absorption Mechanism and Influencial Factors • Absorption Models • Measurements of Dissolved Oxygen (DO), KL a, and Active Oxygen Species • Gaseous Oxygen Measurement • Assessment of KLa • Estimation of Reactive Oxygen Species • Conventional and Novel Bioreactors for Cell Cultures • Microbial Cell Culture Bioreactos • Mammalian Cell Culture Bioreactors • Importance of K.L a in Cell Culture Process Scale up • Acknowledgement • References • New Bioprocessing: Aspects and Strategies: Archaebacterial Bioprocessing: Problems and Developments • Bioprocessing by Cell Synchronization • Recent Advances of Yeast Bioprocessing • Multiinteracting Microbial Bioprocessing: Theory, Benefits and Problems • Strategies of Cycling and Profiling of Variables in Bioprocessing • References • Bioreactors and Biosensors: Introduction • Bioreactors in Bioprocessing of Biocell • Enzyme Bioreactors • Biosensors in Bioprocessing • References • Bioprocessing Scale up: Concerns and Criteria: Introduction • Scale up Concerns of Microbial, Mammalian and Plant Cell Processes • Scale up Criteria • Selection of Scale up Criteria • Scale up Genetically Engineered Cell Culture Fermentation • References • Bioproducts: Modern Estimation and Bioassay : Introduction • Online MS Instrumental Analysis • Light Scattering Instrumental Analysis • Chromatography Instrumental Analysis • Flow Injection Instrumental Analysis (FIIA) • PCR Instrumental Analysis • Few Bioassay Procedures • References • Bioproducts Recovery : Conventional and Newer Methods : Introduction • Conventional Recovery Methods • Newer Methods • References • Treatment Biotechnology of Liquid Wastes and Water: Introduction • General Concerns and Principles • Treatment Biotechnoogy for Waste Waters • Potable Water Treatment Biotechnology • Treatment Biotechnology of Genetically Engineered Cell Processing Efflucnts • References • Control of Undesirable Microorganisms in Biosystems: Introduction • Methods of Controlling Undesirable Microoganisms • Disinfectant Decay and Bacterial Inactivation Kinetics • References • Cellulose Processing Relevance to Process Biotechnology: Introduction • Cellulase: The Complex Resource Conversion Agent • RQ and CQ in T reesei • Approaches of Cellulosic Bioprocessing and Co-product Utility • Further Scope with Lignocellulose Processing Research • Cocktail Enzyme Use in Polysaccharide Systems • References • Bioprocessing: Using Cells Under Stresses : Introduction • Stress Protein Sources and Family Types • Nomenclature of Stress Proteins • Physiological Stress Inducers and Cross Interactive Stresses • SPs Functional Features • Molecular Biology of Cell Processing Under Stress • Kinetics and Dynamics of Stress Proteins Formation • Molecular and Cell Biology (MCB) Techniques in Stress Proteins Analysis • Upstream Bioprocessing and Downstream Separation of SPs • Future Prospects of SPs • Conclusions • Acknowledgement • References • Bioprocess Plant Design Calculations: Penicillin Production System: Introduction • Defining the Design Problem • Fermenter Design Calculation Items • Downstream Process for Recovery by Filtration • Downstream Processing for Extraction • References • Bioprocessing Practice Tutorials : Introduction • Microbial Pure Culture Bioprocessing • Mixed Microbial Cell Cultures • Mammalian Cell Culture System • Plant Cell Culture • Bioproduct Recovery • Additional Practice Tutorials • Miscellaneous Multichoice Questions • References • Substrates for Industrial Process Biotechnology and Their Refining : Introduction • Substrates/Resources • References • Index
