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Description
(Text)
One of the fundamental questions in immunology regards the differences in the generation of immunity versus tolerance. In this thesis, a comprehensive analysis of the functional correlates of CD4+ T cell immunity versus tolerance to soluble protein antigen in vivo is provided.
The author shows that not only in immunity but also in tolerance induction antigen-specific T cells become specifically activated and initially proliferate. However, extensive transcriptome analyses revealed marked differences in the initial gene expression patterns. As a consequence, unlike immunity in tolerance development antigen-specific T cells fail to undergo proper effector differentiation and rapidly disappear from the circulation. In the late phase of the tolerogenic response, regulatory T cells dominate the antigen-specific T cell pool and upon secondary induction of lung inflammation the number of lung-infiltrating antigen-specific T cells is drastically reduced indicating the lack of effector function.
(Author portrait)
Dr. rer. nat. Timo Lischke, born 1978 in Neustrelitz, Germany. 1998-2004 study of biochemistry at the University of Potsdam and graduation with a diploma in the field of immunology. Since 2004, PhD student at the Robert Koch Institute (Berlin) in the Department of Molecular Immunology.
