Virus and RNA Silencing : Polerovirus P0 and its mechanism of action in host plant （2010. 248 S. 220 mm）

PAZHOUHANDEH, Maghsoud

LAP LAMBERT ACADEMIC PUBLISHING（2010発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 248 p.
• 商品コード 9783838311500

Description

(Text)
The poleroviruses are an agronomically important genus of plant viruses which can infect a wide range of hosts. Their genome is a single-stranded plus-sense RNA. The 5'-terminal ORF encodes the 29 kDa protein P0, a strong suppressor of Post- Transcriptional Gene Silencing (PTGS), an important antiviral defense system in plants. I have investigated the mechanism of action of P0 in suppression of RNA silencing. Our data support a model in which P0 acts as an F-box protein, recruiting the post-translational modification system to overcome the post-transcriptional gene silencing system. In this model P0 interacts with SKP to constitute a SCFP0 complex which presumably addresses ARGONAUTE1 that is the slicer protein in the RNA-induced silencing complex (RISC), for ubiquitination and degradation by 26S proteasome. This would be the first example of a suppressor of RNA silencing that acts in an SCF complex to promote degradation of an essential component of the silencing pathway, thereby, inhibiting the plant antiviral defense.
(Author portrait)
PAZHOUHANDEH, MaghsoudHe is presently Assistant Professor in Biotechnology at theAzarbaijan University, Iran. He studied Cellular and MolecularBiology (PhD) at the Louis Pasteur University of Strasbourg,France. He is a researcher on Epigenetic, Plant Virology andPhytopathology.