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Description
(Text)
The conception of substance dependence as a complex brain disorder calls into question folk-psychological views on the voluntary control of behavior and challenges the popular theory of Cartesian dualism. Although brain abnormalities in substance dependence have long been suspected, only in recent years has research begun to more clearly delineate brain alterations, correlating with measurable changes in behavior. However, no characteristic change has been found and the research findings are equivocal. On the other hand, the brain-behavioral connection in substance dependence offers insight into novel therapeutic approaches and helps to remove the pejorative undertone that often surrounds individuals with opioid or other substance dependence.
(Author portrait)
This thesis aims to review the state of research on neurocognitive impairment in substance use disorders, in particular opioid dependence, and to gain more knowledge about the effects of injectable diacetylmorphine when used as a prescription drug. To provide answers, a series of studies were conducted in clinical samples of heroin-dependent patients receiving different forms of opioid maintenance treatment.
