基本説明
Special Topic Issue : Developmental Neuroscience Vol. 33, No. 5 (2011).
Full Description
Down syndrome and Fragile X syndrome are two of the most common developmental disorders of the nervous system in humans. Now that animal models can reliably reproduce many of the phenotypes of these disorders, it has become possible to elucidate the nature of the biological mechanisms that are involved in these two syndromes and new therapeutic options have potentially become available. Highlighting the past, present and future research and the treatment of Down syndrome and Fragile X syndrome, this special topic issue provides a collection of primary research and review articles by leading experts in the field. The broad scope of the articles will be of great interest to both researchers and clinicians in the field of neurodevelopmental disorders.
Contents
The Psychiatric Presentation of Fragile X: Evolution of the Diagnosis and Treatment of the Psychiatric Comorbidities of Fragile X Syndrome: Tranfaglia, M.R.; Fragile X Syndrome: The GABAergic System and Circuit Dysfunction: Paluszkiewicz, S.M.; Martin, B.S.; Huntsman, M.M.; Amygdala Regulation of Fear and Emotionality in Fragile X Syndrome: Olmos-Serrano, J.L.; Corbin, J.G.; What Can We Learn about Autism from Studying Fragile X Syndrome?: Budimirovic, D.B.; Kaufmann, W.E.; The GABAA Receptor Agonist THIP Ameliorates Specific Behavioral Deficits in the Mouse Model of Fragile X Syndrome: Olmos-Serrano, J.L.; Corbin, J.G.; Burns, M.P.; Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities: Liu, C.; Belichenko, P.V.; Zhang, L.; Fu, D.; Kleschevnikov, A.M.; Baldini, A.; Antonarakis, S.E.; Mobley, W.C.; Yu, Y.E.; On the Promise of Pharmacotherapies Targeted at Cognitive and Neurodegenerative Components of Down Syndrome: Costa, A.C.S.; Environmental Enrichment Rescues Postnatal Neurogenesis Defect in the Male and Female Ts65Dn Mouse Model of Down Syndrome: Chakrabarti, L.; Scafidi, J.; Gallo, V.; Haydar, T.F.; G-Protein-Associated Signal Transduction Processes Are Restored after Postweaning Environmental Enrichment in Ts65Dn, a Down Syndrome Mouse Model: Baamonde, C.; Martinez-Cue, C.; Florez, J.; Dierssen, M.; Abnormal MicroRNA Expression in Ts65Dn Hippocampus and Whole Blood: Contributions to Down Syndrome Phenotypes: Keck-Wherley, J.; Grover, D.; Bhattacharyya, S.; Xu, X.; Holman, D.; Lombardini, E.D.; Verma, R.; Biswas, R.; Galdzicki, Z.
