Endothelin in Renal Physiology and Disease (Contributions to Nephrology Vol.172) （2011. 266 S. 35 fig., 9 in color, 3 tab.）

Herausgegeben von Barton, M./ Kohan, D. E./ Ronco, Claudio

KARGER（2011発売）

• 製本 Hardcover:ハードカバー版／ページ数 266 p.／サイズ 35 fig., 6 in color
• 商品コード 9783805597944

Full Description

Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease. This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine. The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development.

Contents

Preface; Molecular Biology and Physiology of Endothelin in the Kidney; Pharmacology of Renal Endothelin Receptors: Davenport, A.P.; Maguire, J.J.; Renal Function and Blood Pressure: Molecular Insights into the Biology of Endothelin-1: Vignon-Zellweger, N.; Heiden, S.; Emoto, N.; Endothelin and the Renal Vasculature: Guan, Z.; Inscho, E.W.; Endothelin Signaling and Actions in the Renal Mesangium: Sorokin, A.; Regulation of Sodium Transport in the Proximal Tubule by Endothelin: Zhang, Y.; Jose, P.A.; Zeng, C.; Role of Endothelin in Thick Ascending Limb Sodium Chloride Transport: Ramseyer, V.D.; Cabral, P.D.; Garvin, J.L.; Endothelins and Kidney Acidification: Wesson, D.E.; Endothelin and Collecting Duct Sodium and Water Transport: Kohan, D.E.; Endothelin Control of Renal Sympathetic Nerve Activity: Kopp, U.C.; Pathophysiology: Endothelin and Renal Disease Mechanisms; Endothelin and Podocyte Injury in Chronic Kidney Disease: Fligny, C.; Barton, M.; Tharaux, P.-L.; Endothelin in Diabetic Renal Disease: Benz, K.; Amann, K.; Endothelin, Nitric Oxide, and Reactive Oxygen Species in Diabetic Kidney Disease: Pollock, J.S.; Pollock, D.M.; Endothelin in Renal Inflammation and Hypertension: Saleh, M.A.; Pollock, D.M.; Endothelin in Chronic Proteinuric Kidney Disease: Gagliardini, E.; Buelli, S.; Benigni, A.; Endothelin in Renal Injury due to Sickle Cell Disease: Tharaux, P.-L.; Endothelin in Polycystic Kidney Disease: Chang, M.-Y.; Ong, A.C.M; Clinical Studies of Endothelin Antagonism in Renal Disease Patients; Endothelin Antagonism and Reversal of Proteinuric Renal Disease in Humans: Barton, M.; Endothelin Antagonism in Patients with Resistant Hypertension and Hypertension Nephropathy: Lazich, I.; Bakris, G.L.; Endothelin Receptor Blockade in Diabetic Nephropathy: Rabelink, T.J.; Kohan, D.E.; Endothelin Antagonism in Patients with Nondiabetic Chronic Kidney Disease: Dhaun, N.; Goddard, J.; Webb, D.J.; Endothelin Antagonists in Clinical Trials: Lessons Learned: Barton, M.; Kohan, D.E.