Epithelial-Mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer : 4th International EMT Meeting, Tucson, Ariz., September 2009. Special Topic Issue: Cells Tissues Organs 2011, Vol. 193, No. 1-2 (Cells Tissues Organs Vol.193/1-2) / Herausgegeben von Thompson, E. W./ Newgreen, D. F./ Savagner, P./ Runyan, R. B.

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Epithelial-Mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer : 4th International EMT Meeting, Tucson, Ariz., September 2009. Special Topic Issue: Cells Tissues Organs 2011, Vol. 193, No. 1-2 (Cells Tissues Organs Vol.193/1-2) （2010. 134 S. 39 fig., 17 in color, 9 tab.）

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Epithelial-Mesenchymal Transitions: New Advances in Development, Fibrosis and Cancer : 4th International EMT Meeting, Tucson, Ariz., September 2009. Special Topic Issue: Cells Tissues Organs 2011, Vol. 193, No. 1-2 (Cells Tissues Organs Vol.193/1-2) （2010. 134 S. 39 fig., 17 in color, 9 tab.）

Herausgegeben von Thompson, E. W./ Newgreen, D. F./ Savagner, P./ Runyan, R. B.

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This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.

Out of the Desert: The 4th TEMTIA Meeting on New Advances in Development, Fibrosis and Cancer: Thompson, E.W.; Runyan, R.; Savagner, P.; Newgreen, D.F.; Emergence of the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Axis in Transforming Growth Factor-[beta]-Induced Epithelial-Mesenchymal Transition: Lamouille, S.; Derynck, R.; Defining the E-Cadherin Repressor Interactome in Epithelial-Mesenchymal Transition: The PMC42 Model as a Case Study: Hugo, H.J.; Kokkinos, M.I.; Blick, T.; Ackland, M.L.; Thompson, E.W.; Newgreen, D.F.; Smaddening Complexity: The Role of Smad3 in Epithelial-Myofibroblast Transition: Masszi, A.; Kapus, A.; Spatiotemporal Localization of Periostin and Its Potential Role in Epithelial-Mesenchymal Transition during Palatal Fusion: Kitase, Y.; Yamashiro, K.; Fu, K.; Richman, J.M.; Shuler, C.F.; Involvement of Dystroglycan in Epithelial-Mesenchymal Transition during Chick Gastrulation: Nakaya, Y.; Sukowati, E.W.; Alev, C.; Nakazawa, F.; Sheng, G.; Angiotensin II and Its Role in Tubular Epithelial to Mesenchymal Transition Associated with Chronic Kidney Disease: Burns, W.C.; Thomas, M.C.; Growth Factors in Induction of Epithelial-Mesenchymal Transition and Metastasis: Said, N.A.B.M.; Williams, E.D.; The Cain and Abl of Epithelial-Mesenchymal Transition and Transforming Growth Factor-[beta] in Mammary Epithelial Cells: Allington, T.M.; Schiemann, W.P.; Cooperative Signaling between Oncostatin M, Hepatocyte Growth Factor and Transforming Growth Factor-[beta] Enhances Epithelial to Mesenchymal Transition in Lung and Pancreatic Tumor Models: Argast, G.M.; Mercado, P.; Mulford, I.J.; O'Connor, M.; Keane, D.M.; Shaaban, S.; Epstein, D.M.; Pachter, J.A.; Kan, J.L.C.; Author and Subject Index.