Free Radical Biology in Digestive Diseases (Frontiers of Gastrointestinal Research Vol.29) （2010. 176 S. 36 fig., 3 in color, 9 tab.）

Herausgegeben von Naito, Y./ Suematsu, M./ Yoshikawa, T./ Rogler, G.

KARGER（2010発売）

• 製本 Hardcover:ハードカバー版／ページ数 188 p.／サイズ 36 figs.
• 商品コード 9783805596091

Full Description

There is a growing body of experimental and clinical data to suggest that the organs of the digestive system may be subjected to considerable oxidative stress associated with acute and chronic inflammation. Although inflammation and ischemia play a key role in producing oxygen-derived free radicals in the digestive tract, the contribution of other factors, such as transition metal imbalances, lipid and glucose metabolic disturbance, and the interaction with gaseous molecules including nitric oxide and carbon monoxide, has also been suggested. Recent studies have demonstrated that several biomarkers indicating oxidative stress-mediated damage may help in monitoring the degree of disease and planning the design of new therapeutic strategies. In addition, recent advances in 'omics' research (genomics, proteomics, metabolomics, etc.) may bring a breakthrough in the field of gastroenterology and hepatology: Several molecular targets for oxidative stress have been presented by the 'omics'. This book includes up-to-date reviews on the relevant issues in free radical biology in a combination with expert basic research reviews and clinical aspects in gastroenterology and hepatology. Providing information about new molecular targets for the treatment or prevention of digestive diseases, this book should be read by clinical and basic researchers in gastroenterology and hepatology.

Contents

Preface: Naito, Y.; Suematsu, M.; Yoshikawa, T.; Free Radical Biology; Free Radicals and Lipid Peroxidation: Niki, E.; Mitochondria as Source of Free Radicals: Majima, H.J.; Indo, H.P.; Suenaga, S.; Kaneko, T.; Matsui, H.; Yen, H.C.; Ozawa, T.; The Nox Family of NADPH Oxidases that Deliberately Produce Reactive Oxygen Species: Sumimoto, H.; Minakami, R.; Miyano, K.; Neutrophil-Dependent Oxidative Stress in Inflammatory Gastrointestinal Diseases: Naito, Y.; Yoshikawa, T.; Oxidative DNA Damage and Carcinogenesis: Jiang, L.; Toyokuni, S.; Plasma Marker of Oxidative Stress in Circulation and in Tissue: Yamamoto, Y.; Immunochemical Detection of 4-Hydroxy-2-Nonenal-Specific Epitopes: Uchida, K.; Carbon Monoxide-Dependent Regulation of Microvascular Function: One Gas Regulates Another: Suematsu, M.; Kajimura, M.; Kabe, Y.; Nrf2-Keap1 Signaling as a Common Chemopreventive Target of Antioxidative and Anti-Inflammatory Phytochemicals: Surh, Y.-J.; Free Radicals in Digestive Diseases; Free Radicals and Gastric Mucosal Injury: Ock, C.Y.; Hong, K.S.; Kim, J.H.; Hahm, K.-B.; Free Radicals in Helicobacter pylori Infection: Suzuki, H.; Nishizawa, T.; Tsugawa, H.; Hibi, T.; Free Radical and Nonsteroidal Anti-Inflammatory Drug-Induced Small Intestinal Injury: Handa, O.; Naito, Y.; Free Radicals in Inflammatory Bowel Disease: Takagi, T.; Naito, Y.; Yoshikawa, T.; Free Radicals and Chronic Hepatitis C: Sakaida, I.; Free Radicals and Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis: Sumida, Y.; Naito, Y.; Yoshikawa, T.; Role of Free Radicals in Pancreatitis: Hamada, S.; Shimosegawa, T.; Free Radicals and Cancer Treatment: Kokura, S.