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Full Description
The development of effective preventive and therapeutic measures to control eating and body weight involves basic physiology as well as cognitive and social psychology. The potential of molecular genetics to illuminate brain-behavior relationships became apparent with the discovery of the leptin gene in 1994. At present, molecular methodologies are being integrated with other physiological approaches, resulting in a number of options from which effective therapeutic strategies may evolve. This book highlights this exciting juncture: Fifteen leading experts present brief descriptions of some of the latest developments of the physiology of eating and weight regulation, ranging from endocrine and neural controls to genetics and functional brain imaging. These Frontier chapters are preceded by a general overview that provides requisite background on the physiology of eating as well as a conceptual framework for the Frontier chapters. Due to its special nature, this book will be of great interest to students at a variety of levels, to basic researchers already in the area or new to it, and to researchers and clinicians interested in translational issues.
Contents
Preface: Langhans, W.; Geary, N.; Introduction - Obesity and Food Intake: Basic and Clinical Approaches: De Kloet, A.D.; Woods, S.C.; Overview of the Physiological Control of Eating: Langhans, W.; Geary, N.; Therapeutic Potential of Gut Peptides: Wolnerhanssen, B.; Beglinger, C.; Roles of Amylin in Satiation, Adiposity and Brain Development: Lutz, T.A.; The Enterocyte as an Energy Flow Sensor in the Control of Eating: Langhans, W.; Development of Hypothalamic Neural Networks Controlling Appetite: Bouret, S.G.; Hypothalamic Nutrient Sensing and Energy Balance: Moran, T.H.; Blood-Brain Barrier as a Regulatory Interface: Banks, W.A.; Do Leptin and Insulin Signal Adiposity? Hillebrand, J.J.G.; Geary, N.; Leptin-Signaling Pathways and Leptin Resistance: Munzberg, H.; Hypothalamic-Brainstem Circuits Controlling Eating: Blevins, J.E.; Baskin, D.G.; Brainstem Integrative Function in the Central Nervous System Control of Food Intake: Schwartz, G.J.; Gaining New Insights into Food Reward with Functional Neuroimaging: Neary, M.T.; Batterham, R.L.; Cortical Mechanisms of Human Eating: Kringelbach, M.L.; Stein, A.; Genetic Variation in Dopaminergic Reward in Humans: Stice, E.; Dagher, A.; Metabolic Imprinting in Obesity: Sullivan, E.L.; Grove, K.L.; Gene-Environment Interactions in Obesity: Hetherington, M.M.; Cecil, J.E.
