基本説明
Repring of: 'Cytogenetic and Genome Research 2004, Vol. 105, No. 2-4'.
Full Description
The house mouse holds a unique place among model organisms, representing an indispensable tool for many investigators, particularly in biomedical research. Mouse genetics encompasses nearly 100 years of research and culminated in the publication of the mouse genome sequence in 2002, from which the idea for this special issue arose. The issue features 37 peer-reviewed papers providing a wide-ranging overview of all major aspects of mouse genetics, from nuclear transfer and embryonic development to cancer, from reproduction to speciation and functional genomics technologies. Its aim is to present a suitable tool of investigation for the large population of researchers that use the mouse as a model animal. Covering a variety of topics, this publication will be a useful guide for scientists working in the fields of reproduction, development, evolution, cancer, toxicology, and cell biology as well as for beginners entering the world of mouse genetics.
Contents
Genome in Development and Cloning; The mouse 'tool box' for meiotic studies: Ashley T; The initiation of homologous chromosome synapsis in mouse fetal oocytes is not directly driven by centromere and telomere clustering in the bouquet: Tankimanova M, Hulten MA, Tease C; Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment: Kolas NK, Yuan L, Hoog C, Heng HHQ, Maroon E, Moens PB; Role of retinoid signaling in the regulation of spermatogenesis: Chung SSW, Wolgemuth DJ; Male germline-specific histones in mouse and man: Churikov D, Zalenskaya IA, Zalensky AO; Single-cell quantitative RT-PCR analysis of Cpt1b and Cpt2 gene expression in mouse antral oocytes and in preimplantation embryos: Gentile L et al.; New mouse genetic models for human contraceptive development: Lessard C et al.; Mouse zona pellucida genes and glycoproteins: Wassarman PM, Jovine L, Litscher ES; Notch-1, c-kit and GFR[alpha]-1 are developmentally regulated markers for premeiotic germ cells: von Schonfeldt V, Wistuba J, Schlatt S; Genome Organization and Function; Spatial genome organization during T-cell differentiation: Kim SH et al.; Positional changes of pericentromeric heterochromatin and nucleoli in postmitotic Purkinje cells during murine cerebellum development: Solovel I et al.; Murine metastable epialleles and transgenerational epigenetic inheritance: Chong S, Whitelaw E; DNA methylation in mouse gametogenesis: Marchal R et al.; DNA methylation profiles of CpG islands for cellular differentiation and development in mammals: Shlota K; Identification and properties of imprinted genes and their control elements: Smith RJ, Arnaud P, Kelsey G; Endogenous reverse transcriptase: a mediator of cell proliferation and differentiation: Spadafora C; Genome and Evolution; Chromosomes and speciation in Mus musculus domesticus: Capanna E, Castiglia R; Mouse biodiversity in the genomic era: Galtier N et al.; The tobacco mouse and its relatives: a 'tail' of coat colors, chromosomes, hybridization and speciation: Hauffe HC et al.; Genomics Technologies and Diseases; RNAi knock-down mice: an emerging technology for post-genomic functional genetics: Prawitt D et al.; Long dsRNA and silent genes strike back: RNAi in mouse oocytes and early embryos: Svoboda P; Sequence-specific modification of mouse genomic DNA mediated by gene targeting techniques: Sangiuolo F, Novelli G; Sox genes and cancer: Dong C, Wilhelm D, Koopman P; Genetic modifiers in mice: the example of the fragile X mouse model: Errijgers V, Kooy RF; The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine models: Smith SK, Kipling D
