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Description
(Text)
Life on earth almost exclusively uses laevorotatory or left-handed amino acids (L-enantiomers), rather than D-enantiomers. Nevertheless, with improved analytical methods, D-amino acids have been detected in a variety of peptides of multi-cellular organisms during recent years. This book takes stock of our present knowledge in this rapidly expanding research area. In a series of chapters it discusses the characterization and analysis of D-amino acids, their occurrence and function in animal peptides and proteins, some possible biosynthetic pathways, and their appearance during ageing. Furthermore, one chapter approaches the puzzling question of homochirality and life.
(Table of content)
Characterization and analysis of d-amino acids.- Characterization and analysis of d-amino acids.- Occurence and function of d-amino acids-containing peptides and proteins.- Occurrence and function of d-amino acids-containing peptides and proteins: Antimicrobial peptides.- Molluscan neuropeptides.- Opioid peptides from frog skin.- d-Amino acids in crustacean hyperglycemic neurohormones.- Biosynthesis: A new family of isomerases.- Biosynthesis of d-amino acid-containing peptides: Exploring the role of peptide isomerases.- Appearance of d-amino acids during aging.- Appearance of d-amino acids during aging: d-Amino acids in tumor proteins.- d-Amino acids in aging erythrocytes.- d-Amino acid hydrolysing enzymes.- d-Amino acid hydrolyzing enzymes.- Homochirality and life.- Homochirality and life.
