Store-operated Ca2+ entry (SOCE) pathways : Emerging Signaling Concepts in Human (patho)Physiology

個数:
電子版価格
¥26,639
  • 電子版あり

Store-operated Ca2+ entry (SOCE) pathways : Emerging Signaling Concepts in Human (patho)Physiology

  • 在庫がございません。海外の書籍取次会社を通じて出版社等からお取り寄せいたします。
    通常6~9週間ほどで発送の見込みですが、商品によってはさらに時間がかかることもございます。
    重要ご説明事項
    1. 納期遅延や、ご入手不能となる場合がございます。
    2. 複数冊ご注文の場合は、ご注文数量が揃ってからまとめて発送いたします。
    3. 美品のご指定は承りかねます。

    ●3Dセキュア導入とクレジットカードによるお支払いについて

  • 提携先の海外書籍取次会社に在庫がございます。通常3週間で発送いたします。
    重要ご説明事項
    1. 納期遅延や、ご入手不能となる場合が若干ございます。
    2. 複数冊ご注文の場合は、ご注文数量が揃ってからまとめて発送いたします。
    3. 美品のご指定は承りかねます。

    ●3Dセキュア導入とクレジットカードによるお支払いについて
  • 【入荷遅延について】
    世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
    おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。
  • ◆画像の表紙や帯等は実物とは異なる場合があります。
  • ◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
    また、洋書販売価格は、ご注文確定時点での日本円価格となります。
    ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。
  • 製本 Hardcover:ハードカバー版/ページ数 481 p./サイズ 56 illus., 32 in color
  • 商品コード 9783709109618

Full Description

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

Contents

Preface (C. Romanin, W. F. Graier, K. Groschner).- SECTION 1: SOCE - Fundamental mechanistic concepts.- Introduction (J. W. Putney).- 1.1 The STIM-Orai pathway.- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura).- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan).- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin).- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem).- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu).- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca).- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina).- SECTION 2: SOCE - Crosstalk between organelle and cellular compartments.- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh).- 2.1 New aspects of the contribut

ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin).- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso).- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu).- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda).- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden).- 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry (R. Malli, W. F. Graier).- 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca2+ signaling (N. Fameli, A. M. Evans, C. van Breemen).- 2.8 Tissue specificity. SOCE - implications for Ca2+ handling in endothelial cells (L. A. Blatter).- SECTION 3: SOCE - Molecular and cellular (patho)physiology.- Introduction (J. A. Rosado).- 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske).- 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak).- 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina).- 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito).- 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz).- 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado).- 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser).- 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh).- 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg).- 3.10: Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin).- 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells - role in egg activation (Z. Machaty, C. Wang, K. Lee).

最近チェックした商品