Full Description
JAK tyrosine kinases and STAT transcription factors constitute a signaling pathway, which is activated by cytokines. By activating gene transcription it regulates essential biological responses to environmental cues. The Jak-Stat pathway is involved in the regulation of cell development, differentiation, proliferation and apoptosis. Improper function may contribute to hematopoietic malignancies and cancer. This book provides comprehensive insights into the latest basic and clinical developments in the field. The first part reviews recent findings and new technologies pertaining to basics of Jak-Stat function. The second part describes the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The third part focuses on Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Finally, chapters in the fourth section describe the relationship of Jak-Stat signaling to various states of disease, particularly infection, leukemias and solid cancers. The book is intended for all scientists in molecular biology, biochemistry and cell biology dealing with biomedical issues.
Contents
The continuing fascination with Jaks and Stats: An introduction .- Regulation of JAKs: Insights gleaned from the functional protein domains .- Nuclear functions of the Janus Kinases .- Self-association of STAT proteins from monomers to paracrystals .- How Stats interact with the molecular machinery of transcriptional activation .- Nongenomic Functions of STAT3 .-Evolution of Jak and Stat proteins .- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses .- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development .- Regulation of dendritic cell development by STATs .- STAT transcription factors - Controlling all aspects of NK cell biology .- Function of JAKs and STATs in lymphocytes: Bench to bedside .- The role of Janus kinases in hematopoietic malignancies .- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated colon cancer .- Universal and specific functions of STAT3 in solid tumours .- Impact of STAT5 on normal tissue development and cancer .- Crosstalk with the Jak-STAT pathway in inflammation .- Activation and inhibition of JAK-STAT signal transduction by RNA viruses .- Multifaceted antiviral actions of interferon-stimulated gene products .- Interferon regulation of the innate response to bacteriaEvolution of Jak and Stat proteins .- JAK/STAT and chromatin regulation in Drosophila . JAK/STAT signaling and invertebrate immune responses .- Stat5 as a hematopoietic master regulator for differentiation and neoplasia development .- Regulation of dendritic cell development by STATs .- STAT transcription factors - Controlling all aspects of NK cell biology .- Function of JAKs and STATs in lymphocytes: Bench to bedside .- The role of Janus kinases in hematopoietic malignancies .- Activation of Janus kinases during tumorigenesis . STAT1 and STAT3 transcription factors in inflammation-associated coloncancer .- Universal and specific functions of STAT3 in solid tumours .- Impact of STAT5 on normal tissue development and cancer .- Crosstalk with the Jak-STAT pathway in inflammation .- Activation and inhibition of JAK-STAT signal transduction by RNA viruses .- Multifaceted antiviral actions of interferon-stimulated gene products .- Interferon regulation of the innate response to bacteria.
