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Full Description
Molecular and Cellular Enzymology addresses not only experienced enzymologists but also students, teachers and academic and industrial researchers who are confronted with enzymological problems during their fundamental or applied research. In this field there is an urgent need for training in order to meet the requirements of both research and industrial endeavours. This book consists of several levels. Practical aspects and elementary explanations are given for the benefit of non-specialists' and students' understanding. In order to facilitate the task of students, two typographies have been adopted. The main text corresponds to basic knowledge, whereas text in a smaller font provides more specialised information. Specialists will also find topics more deeply expounded with the principal bibliographic references cited. The bibliography, however, is not exhaustive; the choice includes general books and review articles as well as some specialised articles. In this book, for the first time, the different molecular and cellular aspects of enzymology are presented together. Until now, there has been no book available in which these different aspects are treated in the same volume. In addition, besides the theoretical developments, this book provides a wealth of practical information for experimentalists.
Contents
Thermodynamics of Enzyme Reactions.- General Introduction.- The Laws of Thermodynamics Concept of Chemical Equilibrium.- Protein-Ligand Association Equilibria.- Living Beings, Open Systems.- Kinetics of Enzymes Reactions in Solution.- Chemical Kinetics.- Kinetics of Enzymatic Reactions with Michaelian Behaviour.- Experimental Methods to Study Enzymatic Reactions.- Formation and Structure of the Active Centre of Enzymes.- Enzyme Origin and Evolution.- Formation of the Functional Structure of Enzymes: Co- and Post-Translational Events.- Topology of the Active Centre of Enzymes.- The Catalytic Function.- Formation of Enzyme-Substrate Complexes.- Catalytic Mechanisms.- Examples of Structure-Function Relationships in Enzymatic Systems.- Regulation of Enzyme Activity.- Regulation by Non-Covalent Interactions.- Regulation by Covalent Modification.- Multifunctional Enzymes, Multi-Enzymatic Complexes and Metabolic Channelling.- Enzymology in Structured Environment.- Localisation and Cellular Compartmentalisation.- Kinetics of Enzymatic Reactions Catalysed by Immobilised Enzymes.- Metabolic Control Theory.
