Total Synthesis of (±)-Maoecrystal V (Springer Theses)

Gong, Jianxian

Springer-Verlag Berlin and Heidelberg GmbH & Co. K（2016/09発売）

• 製本 Paperback:紙装版/ペーパーバック版／ページ数 137 p.
• 商品コード 9783662512890

Full Description

In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.

Contents

Research Background for Natural Product Maoecrystal V and Its Family.- The Model Study of Natural Product Maoecrystal V.- The total synthesis study of Maoecrystal V.- Summary.